Article (Scientific journals)
MicroRNAs tune cerebral cortical neurogenesis.
Volvert, Marie-Laure; Rogister, Florence; Moonen, Gustave et al.
2012In Cell Death and Differentiation, 19 (10), p. 1573-81
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Keywords :
Animals; Cerebral Cortex/metabolism; Humans; MicroRNAs/metabolism; Models, Animal; Neurogenesis; Neuroglia/cytology/metabolism; Ribonuclease III/genetics/metabolism; Stem Cells/cytology/metabolism
Abstract :
[en] MicroRNAs (miRNAs) are non-coding RNAs that promote post-transcriptional silencing of genes involved in a wide range of developmental and pathological processes. It is estimated that most protein-coding genes harbor miRNA recognition sequences in their 3' untranslated region and are thus putative targets. While functions of miRNAs have been extensively characterized in various tissues, their multiple contributions to cerebral cortical development are just beginning to be unveiled. This review aims to outline the evidence collected to date demonstrating a role for miRNAs in cerebral corticogenesis with a particular emphasis on pathways that control the birth and maturation of functional excitatory projection neurons.
Research center :
Giga-Neurosciences - ULiège
Disciplines :
Life sciences: Multidisciplinary, general & others
Neurology
Biochemistry, biophysics & molecular biology
Author, co-author :
Volvert, Marie-Laure 
Rogister, Florence  
Moonen, Gustave  ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Malgrange, Brigitte  ;  Université de Liège - ULiège > GIGA - Neurosciences
Nguyen, Laurent  ;  Université de Liège - ULiège > GIGA - Neurosciences
Language :
English
Title :
MicroRNAs tune cerebral cortical neurogenesis.
Publication date :
2012
Journal title :
Cell Death and Differentiation
ISSN :
1350-9047
eISSN :
1476-5403
Publisher :
Nature Publishing Group, United Kingdom
Volume :
19
Issue :
10
Pages :
1573-81
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
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