Epigenetics, sirtuins and osteoarthritis.

[en] Epigenetics, modifications of the DNA other than changes on the DNA sequences, is frequently studied in cancer research and aging. DNA methylation, mi-RNA, and histones deacetylation are investigated in different pathologies, including inflammatory diseases and age-related diseases such as osteoarthritis (OA). In this review, we focus on the chromatin-modifying enzymes in arthritic pathologies, and more particularly on Sirtuins. We also review the role of Sirt1 in OA, which has been highlighted in recent publications, and examine the possible protective role Sirt1 could play in this disease. Moreover, we discuss the possible therapeutic target of such a protein, reviewing the potential inhibitors/activators of this enzyme and their properties.

Disciplines :

Rheumatology

Author, co-author :

Gabay, Odile

Sanchez, Christelle ; Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.)

Language :

English

Title :

Epigenetics, sirtuins and osteoarthritis.

Publication date :

2012

Journal title :

Joint Bone Spine

ISSN :

1297-319X

eISSN :

1778-7254

Publisher :

Elsevier Masson, Paris, France

Volume :

Issue :

Pages :

570-3

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 04 February 2013

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Bibliography

Loeser R.F. Aging and osteoarthritis. Curr Opin Rheumatol 2011, 23:492-496.
Valdes A.M., Spector T.D. Genetic epidemiology of hip and knee osteoarthritis. Nat Rev Rheumatol 2011, 7:23-32.
Spector T.D., MacGregor A.J. Risk factors for osteoarthritis: genetics. Osteoarthritis Cartilage 2004, 12:S39-S44.
Valdes A.M., Van Oene M., Hart D.J., et al. Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. Arthritis Rheum 2006, 54:533-539.
Livshits G., Kato B.S., Zhai G., et al. Genomewide linkage scan of hand osteoarthritis in female twin pairs showing replication of quantitative trait loci on chromosomes 2 and 19. Ann Rheum Dis 2007, 66:623-627.
Bird A. Perceptions of epigenetics. Nature 2007, 447:396-398.
Sesselmann S., Soder S., Voigt R., et al. DNA methylation is not responsible for p21WAF1/CIP1 down-regulation in osteoarthritic chondrocytes. Osteoarthritis Cartilage 2009, 17:507-512.
Roach H.I., Yamada N., Cheung K.S., et al. Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions. Arthritis Rheum 2005, 52:3110-3124.
Tardif G., Hum D., Pelletier J.P., et al. Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes. BMC Musculoskelet Disord 2009, 10:148.
Miyaki S., Nakasa T., Otsuki S., et al. MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses. Arthritis Rheum 2009, 60:2723-2730.
Tuddenham L., Wheeler G., Ntounia-Fousara S., et al. The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells. FEBS Lett 2006, 580:4214-4217.
Miyaki S., Sato T., Inoue A., et al. MicroRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev 2010, 24:1173-1185.
Iliopoulos D., Malizos K.N., Oikonomou P., et al. Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks. PLoS One 2008, 3:e3740.
Inoue T., Hiratsuka M., Osaki M., et al. The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation. Cell Cycle 2007, 6:1011-1018.
Balcerczyk A., Pirola L. Therapeutic potential of activators and inhibitors of sirtuins. Biofactors 2010, 36:383-393.
Kaeberlein M., McVey M., Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 1999, 13:2570-2580.
Frye R.A. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun 2000, 273:793-798.
Vaziri H., Dessain S.K., Ng Eaton E., et al. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 2001, 107:149-159.
Saunders L.R., Verdin E. Sirtuins: critical regulators at the crossroads between cancer and aging. Oncogene 2007, 26:5489-5504.
Dvir-Ginzberg M., Gagarina V., Lee E.J., et al. Tumor necrosis factor alpha-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes. Arthritis Rheum 2011, 63:2363-2373.
Oppenheimer H., Gabay O., Meir H., et al. 75kDa SirT1 blocks TNFalpha-mediated apoptosis in human osteoarthritic chondrocytes. Arthritis Rheum 2012, 64:718-728.
Haigis M.C., Sinclair D.A. Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol 2010, 5:253-295.
Sinclair D.A. Toward a unified theory of caloric restriction and longevity regulation. Mech Ageing Dev 2005, 126:987-1002.
Brooks C.L., Gu W. How does SIRT1 affect metabolism, senescence and cancer?. Nat Rev Cancer 2009, 9:123-128.
Li X., Zhang S., Blander G., et al. SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol Cell 2007, 28:91-106.
Sasaki Y., Vohra B.P., Baloh R.H., et al. Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo. J Neurosci 2009, 29:6526-6534.
Csiszar A., Smith K., Labinskyy N., et al. Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: role of NF-kappaB inhibition. Am J Physiol Heart Circ Physiol 2006, 291:H1694-H1699.
Shen Z., Liang X., Rogers C.Q., et al. Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice. Am J Physiol Gastrointest Liver Physiol 2010, 298:G364-G374.
Yoshizaki T., Milne J.C., Imamura T., et al. SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Mol Cell Biol 2009, 29:1363-1374.
Zu Y., Liu L., Lee M.Y., et al. SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells. Circ Res 2010, 106:1384-1393.
Qiao A.J., Zhiao J., Liu X.J., et al. Research advances in Sirt1 gene. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2009, 31:782-785.
Zhang Z., Lowry S.F., Guarente L., et al. Roles of SIRT1 in the acute and restorative phases following induction of inflammation. J Biol Chem 2010, 285:41391-41401.
Yoshizaki T., Schenk S., Imamura T., et al. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am J Physiol Endocrinol Metab 2010, 298:E419-E428.
Fujita N., Matsushita T., Ishida K., et al. Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions. J Orthop Res 2011, 29:511-515.
Gagarina V., Gabay O., Dvir-Ginzberg M., et al. SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway. Arthritis Rheum 2010, 62:1383-1392.
Takayama K., Ishida K., Matsushita T., et al. SIRT1 regulation of apoptosis of human chondrocytes. Arthritis Rheum 2009, 60:2731-2740.
Dvir-Ginzberg M., Gagarina V., Lee E.J., et al. Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase. J Biol Chem 2008, 283:36300-36310.
Hong E.H., Lee S.J., Kim J.S., Lee K.H., Um H.D., Kim J.H., et al. Ionizing radiation induces cellular senescence of articular chondrocytes via negative regulation of SIRT1 by p38 kinase. J Biol Chem 2010, 285:1283-1295.
Huber L.C., Stanczyk J., Jungel A., et al. Epigenetics in inflammatory rheumatic diseases. Arthritis Rheum 2007, 56:3523-3531.
Niederer F., Ospelt C., Brentano F., et al. SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance. Ann Rheum Dis 2011, 70:1866-1873.
McBurney M.W., Yang X., Jardine K., et al. The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol 2003, 23:38-54.
Sequeira J., Boily G., Bazinet S., et al. sirt1-null mice develop an autoimmune-like condition. Exp Cell Res 2008, 314:3069-3074.
Boily G., He X.H., Pearce B., et al. SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol. Oncogene 2009, 28:2882-2893.
Cheng H.L., Mostoslavsky R., Saito S., et al. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A 2003, 100:10794-10799.
Bordone L., Cohen D., Robinson A., et al. SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 2007, 6:759-767.
Seifert E.L., Caron A.Z., Morin K., et al. SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice. FASEB J. 2012, 26:555-566.
Gabay O., Sanchez C., Oppenheimer H., et al. Increase of apoptosis in the Sirt1 heterozygous mice cartilage. Ann Rheum Dis 2012, 71:613-616.
Grabiec A.M., Tak P.P., Reedquist K.A. Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on?. Arthritis Res Ther 2008, 10:226.
Nakamura T., Kukita T., Shobuike T., et al. Inhibition of histone deacetylase suppresses osteoclastogenesis and bone destruction by inducing IFN-beta production. J Immunol 2005, 175:5809-5816.
Shakibaei M., Buhrmann C., Mobasheri A. Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappaB ligand (RANKL) activation of NF-kappaB signaling and inhibit osteoclastogenesis in bone-derived cells. J Biol Chem 2011, 286:11492-11505.
Chabane N., Zayed N., Afif H., et al. Histone deacetylase inhibitors suppress interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes. Osteoarthritis Cartilage 2008, 16:1267-1274.
Young D.A., Lakey R.L., Pennington C.J., et al. Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption. Arthritis Res Ther 2005, 7:R503-R512.
Nishida K., Komiyama T., Miyazawa S., et al. Histone deacetylase inhibitor suppression of autoantibody-mediated arthritis in mice via regulation of p16INK4a and p21 (WAF1/Cip1) expression. Arthritis Rheum 2004, 50:3365-3376.
Kim J.E., Chen J., Lou Z. DBC1 is a negative regulator of SIRT1. Nature 2008, 451:583-586.
Zhao W., Kruse J.P., Tang Y., et al. Negative regulation of the deacetylase SIRT1 by DBC1. Nature 2008, 451:587-590.
Anekonda T.S., Reddy P.H. Neuronal protection by sirtuins in Alzheimer's disease. J Neurochem 2006, 96:305-313.
Howitz K.T., Bitterman K.J., Cohen H.Y., et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003, 425:191-196.
Baur J.A., Pearson K.J., Price N.L., et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006, 444:337-342.
Um J.H., Park S.J., Kang H., et al. AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes 2010, 59:554-563.
Milne J.C., Lambert P.D., Schenk S., et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 2007, 450:712-716.