Article (Scientific journals)
Cumulative pregnancy rate after ICSI-IVF in patients with colorectal endometriosis: results of a multicentre study.
Ballester, Marcos; d'Argent, EM; Morcel, K et al.
2012In Human Reproduction, 27 (4), p. 1043-9
Peer Reviewed verified by ORBi
 

Files


Full Text
Ballester Hum. Reprod.-2012.pdf
Publisher postprint (285.89 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
colorectal endometriosis; ICSI–IVF; cumulative pregnancy rate; adenomyosis; AMH
Abstract :
[en] BACKGROUND: There is currently no consensus about indications for surgery for infertility associated with colorectal endometriosis. The aim of this study was to evaluate cumulative pregnancy rates (CPRs) after ICSI-IVF cycles in patients with colorectal endometriosis and to identify determinant factors of fertility outcome. METHODS: Prospective longitudinal multicentre study from January 2005 to June 2011. We included 75 patients with colorectal endometriosis and proved infertility without prior surgery for deep infiltrating endometriosis. Univariable analysis was used to identify determinant factors of pregnancy rate. CPR was calculated using cumulative-incidence methods from log-rank test and Kaplan-Meier curves. For multivariable analysis, Cox proportional hazards model was used. RESULTS: For CPR per patient analysis, the total number of cycles was 113 and the median number of cycles per patient was 1 (range: 1-3). In the whole population the CPR per patient after three ICSI-IVF cycles was 68.6%. The CPR for patients with or without associated adenomyosis was 19 and 82.4%, respectively (P= 0.01). In addition, a patient age over 35 years (P= 0.02) and anti-Mullerian hormone serum level under 2 ng/ml (P= 0.02) were associated with a decreased CPR per patient. At multivariable analysis, adenomyosis [HR = 0.34, 95% CI (0.12-0.99), P= 0.49] was associated with a decreased CPR. CONCLUSIONS: Our data confirm that ICSI-IVF offers a high CPR per patient. However, determinant factors of CPR should be taken into account when informing couples of their options.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
Ballester, Marcos
d'Argent, EM
Morcel, K
Belaisch-Allart, J
Nisolle, Michelle ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Darai, Erik
Language :
English
Title :
Cumulative pregnancy rate after ICSI-IVF in patients with colorectal endometriosis: results of a multicentre study.
Publication date :
April 2012
Journal title :
Human Reproduction
ISSN :
0268-1161
eISSN :
1460-2350
Publisher :
Oxford University Press, Oxford, United Kingdom
Volume :
27
Issue :
4
Pages :
1043-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 31 January 2013

Statistics


Number of views
260 (10 by ULiège)
Number of downloads
374 (6 by ULiège)

Scopus citations®
 
96
Scopus citations®
without self-citations
81
OpenCitations
 
82

Bibliography


Similar publications



Contact ORBi