Article (Scientific journals)
Insulin sensitivity modulates the growth response during the first year of high-dose growth hormone treatment in short prepubertal children born small for gestational age.
Gies, Inge; Thomas, Muriel; Tenoutasse, Sylvie et al.
2012In Hormone Research in Paediatrics, 78 (1), p. 24-30
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Keywords :
Age Factors; Body Height/drug effects/physiology; Child; Child Development/drug effects/physiology; Child, Preschool; Dose-Response Relationship, Drug; Female; Growth Disorders/drug therapy/metabolism; Human Growth Hormone/therapeutic use; Humans; Infant, Newborn; Infant, Small for Gestational Age/growth & development/metabolism; Insulin Resistance/physiology; Male; Puberty/metabolism/physiology; Time Factors; Treatment Outcome
Abstract :
[en] AIM: To study the relationship between insulin sensitivity and growth response in short children born small for gestational age (SGA) treated with growth hormone (GH). METHODS: Randomized, open-label, 24-month intervention study in 40 short prepubertal SGA children [age (mean +/- SD) 5.3 +/- 1.5 years], who either remained untreated (n = 20) or were treated with GH (66 microg/kg/day; n = 20). Changes in fasting glucose, insulin, quantitative insulin sensitivity check index (QUICKI), IGF-1 and leptin after 1 and 2 years were studied. RESULTS: Mean height SDS increased from -3.3 +/- 0.7 to -2.3 +/- 0.7 after 1 year, and to -1.9 +/- 0.7 after 2 years of treatment. QUICKI decreased significantly (p = 0.008) in the first year of GH treatment and stabilized in the second year. Baseline QUICKI was positively associated (r = 0.40; p < 0.05) with the change in height SDS in the first year. CONCLUSION: Higher insulin sensitivity at the start of GH therapy is associated with greater first-year growth response to GH, and could be a promising parameter in selecting prepubertal short SGA children for GH treatment. However, this finding needs to be confirmed in larger studies.
Disciplines :
Pediatrics
Author, co-author :
Gies, Inge
Thomas, Muriel
Tenoutasse, Sylvie
De Waele, Kathleen
LEBRETHON, Marie-Christine ;  Centre Hospitalier Universitaire de Liège - CHU > Pédiatrie
Beckers, Dominique
Francois, Inge
Maes, Marc
Rooman, Raoul
de Beaufort, Carine
Massa, Guy
De Schepper, Jean
Language :
English
Title :
Insulin sensitivity modulates the growth response during the first year of high-dose growth hormone treatment in short prepubertal children born small for gestational age.
Publication date :
2012
Journal title :
Hormone Research in Paediatrics
ISSN :
1663-2818
eISSN :
1663-2826
Publisher :
Karger, Basel, Switzerland
Volume :
78
Issue :
1
Pages :
24-30
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2012 S. Karger AG, Basel.
Available on ORBi :
since 31 January 2013

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