Chronic Herpes Simplex Virus Type I Glossitis in an Immunocompromised Man

[en] Herpes simplex virus (HSV) type 1 (HSV-1) infection of the tongue commonly accompanies acute primary herpetic gingivostomatitis. However, recurrent infection of the tongue is exceptional and is restricted to immunocompromised individuals. A 57-year-old man with corticosteroid-dependent chronic obstructive pulmonary disease and sciatica presented with a chronic median glossitis due to HSV-1. The main clinical and histological feature was massive necrosis of the entire mucosa. Immunohistochemistry demonstrated a considerable amount of HSV gB, gC and gD envelope glycoproteins dispersed in the chorion. In contrast, HSV-1 DNA was detected only in a limited number of epithelial cells using in situ hybridization. The extent of necrosis and the pattern of viral DNA and envelope protein distribution represent unique features of median herpetic glossitis, which are not found in more common types of HSV infection.

Disciplines :

Dermatology

Author, co-author :

Nikkels, Arjen ; Université de Liège - ULiège > Dermatologie

Pierard, Gérald ; Université de Liège - ULiège > Dermatopathologie

Language :

English

Title :

Chronic Herpes Simplex Virus Type I Glossitis in an Immunocompromised Man

Publication date :

February 1999

Journal title :

British Journal of Dermatology

ISSN :

0007-0963

eISSN :

1365-2133

Publisher :

Wiley, Oxford, United Kingdom

Volume :

140

Issue :

Pages :

343-346

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 12 March 2010

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Bibliography

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