Article (Scientific journals)
Effet de la deleucocytation des concentres erythrocytaires sur les reactions transfusionnelles.
Mukagatare, I.; MONFORT, Mélanie; de Marchin, J. et al.
2010In Transfusion Clinique et Biologique, 17 (1), p. 14-9
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Keywords :
Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Erythrocyte Transfusion/adverse effects; Female; Fever/etiology/prevention & control; Humans; Hypersensitivity/etiology/prevention & control; Hypotension/etiology/prevention & control; Infant; Leukocyte Reduction Procedures; Male; Middle Aged; Pulmonary Edema/etiology/prevention & control; Retrospective Studies; Young Adult
Abstract :
[en] SUBJECT: In order to assess the impact of leukocyte reduction, all transfusion reactions reported at Liege Teaching Hospital's Blood Bank 2 years before and after the implementation of universal leukocyte reduction of red blood cells concentrates which started-up on 1 January 2005 were evaluated. STUDY DESIGN AND METHODS: A retrospective analysis of transfusion reactions from 1 January 2003 to 31st December 2006 was undertaken. Data were collected from computerized reports, which were entered as soon as a transfusion reaction was reported. Symptoms were classified in different reaction's categories. Blood cultures, antibody screening and direct antiglobulin test were performed. Differences between the two time periods, before (2003-2004) and after (2005-2006) universal leukoreduction were determined by the Chi-square test and significance was defined as a p value less than 0.05. RESULTS: During period before the implementation of systematic leukoreduction, 68.7% of red blood cells transfused were leukoreduced. A total of 365 transfusion reactions in 91,996 red blood cells units transfused (0.4%) were reported, of which 266 were classified as febrile non-hemolytic transfusion reactions (72.9%), followed by allergic reactions (7.1%) and miscellaneous reactions (3.8%). When comparing the two-time periods, the rate of all transfusion reactions in general significantly decreased from 0.49 to 0.31% (p<0.001). Therefore, universal leukocyte reduction significantly reduced the rates of febrile non-hemolytic transfusion reactions (0.35% versus 0.24%; p=0.002) and allergic reactions (0.05% versus 0.01%; p<0.001). CONCLUSION: Universal leukocyte reduction significantly reduced the rate of transfusion reactions.
Disciplines :
Hematology
Author, co-author :
Mukagatare, I.
MONFORT, Mélanie ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie biologique et immuno hématologie
de Marchin, J.
GERARD, Christiane ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie biologique et immuno hématologie
Language :
French
Title :
Effet de la deleucocytation des concentres erythrocytaires sur les reactions transfusionnelles.
Alternative titles :
[en] The effect of leukocyte-reduction on the transfusion reactions to red blood cells concentrates
Publication date :
2010
Journal title :
Transfusion Clinique et Biologique
ISSN :
1246-7820
eISSN :
1953-8022
Publisher :
Elsevier, Paris, France
Volume :
17
Issue :
1
Pages :
14-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 29 January 2013

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