Article (Scientific journals)
Recognition of the latency-associated immediate early protein IE63 of varicella-zoster virus by human memory T-lymphocytes
Sadzot-Delvaux, Catherine; Kinchington, Paul R.; Debrus, Serge et al.
1997In Journal of Immunology, 159 (6), p. 2802-2806
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Keywords :
Varicella-Zoster; Viral Latency; VZV proteins
Abstract :
[en] Varicella-zoster virus (VZV) is a human alpha herpesvirus that establishes latency in sensory ganglia. Latency is characterized by the abundant expression of the immediate early protein 63 (IE63), whereas other viral proteins have not yet been detected during the quiescent phase of VZV infection. The IE63 protein is a component of the virion and is expressed very early in the infectious cycle. The IE63 protein is also expressed in skin during episodes of varicella and herpes zoster. We have evaluated the cell-mediated immune response against IE63 in naturally immune adults with a history of chickenpox, by T lymphoproliferation and cytotoxicity assays. Among donors who had T cell proliferation to unfractionated VZV Ags from infected cell extract, 59% had T cell recognition of purified IE63. The CTL response to IE63 was equivalent to CTL recognition of IE62, the major tegument component of VZV whose immunogenicity has been previously described. IgG Abs against IE63 were detected in serum from healthy immune adults. These results indicate that IE63 is an important target of immunity to VZV. T cell recognition of IE63 is likely to be involved in controlling VZV reactivation from latency.
Disciplines :
Immunology & infectious disease
Author, co-author :
Sadzot-Delvaux, Catherine ;  Université de Liège - ULiège > Département des sciences de la vie > Virologie et immunologie
Kinchington, Paul R.;  University of Buffalo, NY, USA
Debrus, Serge;  Université de Liège - ULiège > Département des Sciences de la Vie > Virologie & Immunologie fondamentales
Rentier, Bernard  ;  Université de Liège - ULiège > Département de Microbiologie > Virologie fondamentale et Immunologie
Arvin, Ann M.;  Stanford University, CA, USA
Language :
English
Title :
Recognition of the latency-associated immediate early protein IE63 of varicella-zoster virus by human memory T-lymphocytes
Publication date :
1997
Journal title :
Journal of Immunology
ISSN :
0022-1767
eISSN :
1550-6606
Publisher :
American Association of Immunologists, Baltimore, United States - Maryland
Volume :
159
Issue :
6
Pages :
2802-2806
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 November 2008

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