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Glipizide increases plasma insulin but not C-peptide level after a standardized breakfast in type 2 diabetic patients.
Scheen, André; Lefebvre, Pierre; Luyckx, A. S.
1984In European Journal of Clinical Pharmacology, 26 (4), p. 471-4
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Keywords :
Blood Glucose/analysis; C-Peptide/blood; Diabetes Mellitus, Type 2/blood/drug therapy; Eating; Female; Glipizide/administration & dosage/pharmacology/therapeutic use; Humans; Insulin/blood; Male; Middle Aged; Stimulation, Chemical; Sulfonylurea Compounds/pharmacology
Abstract :
[en] Peripheral blood glucose, plasma insulin and C-peptide levels were investigated after giving a standardized breakfast (500 kcal, 60 g carbohydrates) to 10 nonobese Type 2 diabetic patients previously treated by diet alone. Each patient received at random, at 1 week intervals, either 5 mg glipizide (meal + glipizide) or a placebo (meal alone) 30 min before breakfast. Basal values of blood glucose, plasma insulin and C-peptide were similar on both occasions. After meal + glipizide, the blood glucose increase was sharply limited whereas the rise in plasma insulin was steeper and reached twice as high a level. In contrast, the rise in plasma C-peptide was similar in both conditions. Consequently, the areas under the curves (0-300 min) showed a marked reduction in blood glucose after meal + glipizide (2289 +/- 149 versus 3101 +/- 169 mmol X min/1; 2p less than 0.001), associated with a significant increase in plasma insulin (14219 +/- 3261 versus 7591 +/- 1173 microU X min/ml; 2p less than 0.025) but no significant change in plasma C-peptide (342 +/- 45 versus 326 +/- 34 pmol X min/ml; N.S.). The insulin/C-peptide molar ratio was thus significantly increased after meal + glipizide (0.41 +/- 0.06 versus 0.23 +/- 0.04 at the 60th min; 2p less than 0.02). The dissociation between the responses of insulin and C-peptide suggests that a single dose of 5 mg glipizide in Type 2 diabetic subjects may enhance availability of peripheral insulin by extrapancreatic mechanism(s). This phenomenon may result in a higher circulating level of the hormone and therefore represent a further mode of action of sulphonylureas.(ABSTRACT TRUNCATED AT 250 WORDS)
Disciplines :
Pharmacy, pharmacology & toxicology
Endocrinology, metabolism & nutrition
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Lefebvre, Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques
Luyckx, A. S.
Language :
English
Title :
Glipizide increases plasma insulin but not C-peptide level after a standardized breakfast in type 2 diabetic patients.
Publication date :
1984
Journal title :
European Journal of Clinical Pharmacology
ISSN :
0031-6970
eISSN :
1432-1041
Publisher :
Springer Verlag, Berlin, Germany
Volume :
26
Issue :
4
Pages :
471-4
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 08 June 2009

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