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U-100 insulin gives some protection against metabolic deterioration due to CSII interruption.
Scheen, André; Henrivaux, P.; Jandrain, Bernard et al.
1987In Diabetes Care, 10 (6), p. 707-11
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Keywords :
3-Hydroxybutyric Acid; Adult; Blood Glucose/metabolism; C-Peptide/blood; Diabetes Mellitus, Type 1/blood/drug therapy; Drug Administration Schedule; Fatty Acids, Nonesterified/blood; Female; Humans; Hydroxybutyrates/blood; Insulin/administration & dosage/blood; Insulin Infusion Systems; Male; Middle Aged; Time Factors
Abstract :
[en] We investigated the influence of insulin concentration within the insulin pump on the metabolic and plasma free-insulin changes induced by a 6-h nocturnal interruption of continuous subcutaneous insulin infusion (CSII) in five C-peptide-negative insulin-dependent diabetic patients with low circulating levels of anti-insulin antibodies. We compared the changes in blood glucose, plasma free fatty acids, 3-hydroxybutyrate, and free insulin during the interruption from 2300 to 0500 h of the Nordisk Infuser loaded with either U-100 or U-20 regular insulin. The decrease in plasma free-insulin levels was slower, resulting in a significantly delayed and smaller increase in blood glucose levels (2.4 +/- 1.6 vs. 7.6 +/- 2.9 mM, P less than .025) when the pump contained U-100 instead of U-20 insulin. Although the increases in levels of plasma free fatty acids were similar in both tests, the rise in plasma 3-hydroxybutyrate levels tended to be reduced with U-100 insulin (414 +/- 139 vs. 639 +/- 67 microM, P less than .10). Thus, our observations indicate that U-100 insulin gives some protection against the metabolic deterioration due to the interruption of CSII so that diabetic patients may be able to remain without the pump for longer periods with concentrated rather than diluted insulin.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Henrivaux, P.
Jandrain, Bernard ;  Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques
Lefebvre, Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques
Language :
English
Title :
U-100 insulin gives some protection against metabolic deterioration due to CSII interruption.
Publication date :
1987
Journal title :
Diabetes Care
ISSN :
0149-5992
eISSN :
1935-5548
Publisher :
American Diabetes Association, Alexandria, United States - Virginia
Volume :
10
Issue :
6
Pages :
707-11
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 08 June 2009

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