Article (Scientific journals)
In vitro and in vivo antimalarial properties of isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis
Frederich, Michel; Tits, Monique; Goffin, Eric et al.
2004In Planta Medica, 70 (6), p. 520-525
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Keywords :
Plasmodium falciparum; Plasmodium berghei; Plasmodium vinckei; isostrychnopentamine; Strychnos usambarensis; loganiaceae
Abstract :
[en] Isostrychnopentamine (ISP) is an asymmetric indolomonoterpenic alkaloid isolated from the leaves of Strychnos usambarensis. The in vitro antiplasmodial activities against five Plasmodium falciparum cell lines were evaluated: ISP possessed an in vitro IC (50) near 0.1 microM against all P. falciparum cell lines tested (chloroquine-resistant and chloroquine-sensitive lines) and showed antiplasmodial selectivity compared to cytotoxicity on human cell lines. The stage-dependent susceptibility to a short exposure of ISP was then investigated. The ring stage was shown to be the most sensitive one, but all stages were affected by ISP treatment. By means of fluorescence microscopy, it was shown that ISP was not accumulated inside the food vacuole of the parasite. Finally, the in vivo antimalarial activities against the P. berghei NK173 and P. vinckei petteri murine strains were determined. The ED (50) in vivo was about 30 mg/kg/day by the intraperitoneal route (after 4 days treatment).
Disciplines :
Chemistry
Phytobiology (plant sciences, forestry, mycology...)
Pharmacy, pharmacology & toxicology
Author, co-author :
Frederich, Michel  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Tits, Monique ;  Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie
Goffin, Eric ;  Université de Liège - ULiège > Chimie pharmaceutique
Philippe, Geneviève  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Grellier, P.
De Mol, Patrick ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale
Hayette, Marie-Pierre ;  Université de Liège - ULiège > Microbiologie médicale
Angenot, Luc  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
English
Title :
In vitro and in vivo antimalarial properties of isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis
Publication date :
June 2004
Journal title :
Planta Medica
ISSN :
0032-0943
eISSN :
1439-0221
Publisher :
Georg Thieme Verlag Kg, Stuttgart, Germany
Volume :
70
Issue :
6
Pages :
520-525
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 05 June 2009

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