ORBi: Scheen André - Effects of a 1-year treatment with a low-dose combined oral contraceptive containing ethinyl estradiol and cyproterone acetate on glucose and insulin metabolism.

Reference : Effects of a 1-year treatment with a low-dose combined oral contraceptive containing eth...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Pharmacy, pharmacology & toxicology Human health sciences : Endocrinology, metabolism & nutrition
	To cite this reference:	http://hdl.handle.net/2268/14020

Title :	Effects of a 1-year treatment with a low-dose combined oral contraceptive containing ethinyl estradiol and cyproterone acetate on glucose and insulin metabolism.
Language :	English
Author, co-author :	Scheen, André [Université de Liège - ULg > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale >]
	Jandrain, Bernard [Centre Hospitalier Universitaire de Liège - CHU > > Diabétologie,nutrition, maladies métaboliques >]
	Humblet, Dominique [Centre Hospitalier Universitaire de Liège - CHU > > Ophtalmologie >]
	Jaminet, C. B. [> > > >]
	Gaspard, Ulysse [Centre Hospitalier Universitaire de Liège - CHU > > Gynécologie-Obstétrique >]
	Lefebvre, Pierre [Centre Hospitalier Universitaire de Liège - CHU > > Diabétologie,nutrition, maladies métaboliques >]
Publication date :	1993
Journal title :	Fertility and Sterility
Publisher :	Elsevier
Volume :	59
Issue/season :	4
Pages :	797-802
ISSN :	0015-0282
e-ISSN :	1556-5653
City :	New York
Country :	NY
Keywords :	[en] Adult ; C-Peptide/analysis ; Contraceptives, Oral, Combined/pharmacology ; Cyproterone Acetate/pharmacology ; Drug Combinations ; Ethinyl Estradiol/pharmacology ; Female ; Glucose/metabolism ; Glucose Tolerance Test ; Humans ; Insulin/metabolism/pharmacology ; Metabolic Clearance Rate ; OT - Biology ; OT - Carbohydrate Metabolic Effects ; OT - Contraception ; OT - Contraceptive Methods ; OT - Family Planning ; OT - Glucose Metabolism Effects ; OT - Metabolic Effects ; OT - Oral Contraceptives ; OT - Oral Contraceptives, Combined ; OT - Oral Contraceptives, Low-dose ; OT - Physiology ; OT - Prospective Studies ; OT - Research Methodology ; OT - Research Report ; OT - Studies
Abstract :	[en] OBJECTIVE: To study the effects of the slightly estrogen-dominant monophasic low-dose oral contraceptive (OC) Diane-35 (Schering AG, Berlin, Germany) (35 micrograms ethinyl estradiol [EE2] + 2 mg cyproterone acetate, a 17 alpha-hydroxyprogesterone derivative [17-OHP]) on glucose and insulin metabolism. DESIGN: Seven healthy young women were investigated by using the euglycemic hyperinsulinemic glucose clamp technique (insulin delivery rate = 100 mU/kg per hour for 120 minutes). This test was performed, after an overnight fast, during the last 7 days of a spontaneous cycle and within the last 5 days of pill intake during the sixth and twelfth cycle of a continuous treatment with Diane-35 in each subject. RESULTS: The three indexes measuring the insulin-induced glucose disposal during the clamp (glucose infusion rate, glucose metabolic clearance rate, and glucose infusion rate divided by plasma insulin plateau levels) were not significantly affected by Diane-35. In contrast, the metabolic clearance rate of the exogenous insulin infused during the clamp tended to be slightly increased with Diane-35 (significant after 6 but not after 12 cycles). CONCLUSION: These results suggest that a 1-year treatment with the OC Diane-35, which contains EE2 + a 17-OHP rather than a 19-nortestosterone derivative as the progestogen compound, does not significantly alter peripheral (presumably muscular) insulin sensitivity but slightly increases insulin (presumably hepatic) clearance.
Funders :	PIP: TJ: FERTILITY AND STERILITY.
Permalink :	http://hdl.handle.net/2268/14020

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