Reference : Effects of a 1-year treatment with a low-dose combined oral contraceptive containing eth...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
Human health sciences : Endocrinology, metabolism & nutrition
http://hdl.handle.net/2268/14020
Effects of a 1-year treatment with a low-dose combined oral contraceptive containing ethinyl estradiol and cyproterone acetate on glucose and insulin metabolism.
English
Scheen, André mailto [Université de Liège - ULg > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale >]
Jandrain, Bernard mailto [Centre Hospitalier Universitaire de Liège - CHU > > Diabétologie,nutrition, maladies métaboliques >]
Humblet, Dominique [Centre Hospitalier Universitaire de Liège - CHU > > Ophtalmologie >]
Jaminet, C. B. [> > > >]
Gaspard, Ulysse mailto [Centre Hospitalier Universitaire de Liège - CHU > > Gynécologie-Obstétrique >]
Lefebvre, Pierre [Centre Hospitalier Universitaire de Liège - CHU > > Diabétologie,nutrition, maladies métaboliques >]
1993
Fertility and Sterility
Elsevier
59
4
797-802
Yes (verified by ORBi)
0015-0282
1556-5653
New York
NY
[en] Adult ; C-Peptide/analysis ; Contraceptives, Oral, Combined/pharmacology ; Cyproterone Acetate/pharmacology ; Drug Combinations ; Ethinyl Estradiol/pharmacology ; Female ; Glucose/metabolism ; Glucose Tolerance Test ; Humans ; Insulin/metabolism/pharmacology ; Metabolic Clearance Rate ; OT - Biology ; OT - Carbohydrate Metabolic Effects ; OT - Contraception ; OT - Contraceptive Methods ; OT - Family Planning ; OT - *Glucose Metabolism Effects ; OT - *Metabolic Effects ; OT - Oral Contraceptives ; OT - *Oral Contraceptives, Combined ; OT - *Oral Contraceptives, Low-dose ; OT - Physiology ; OT - *Prospective Studies ; OT - Research Methodology ; OT - *Research Report ; OT - Studies
[en] OBJECTIVE: To study the effects of the slightly estrogen-dominant monophasic low-dose oral contraceptive (OC) Diane-35 (Schering AG, Berlin, Germany) (35 micrograms ethinyl estradiol [EE2] + 2 mg cyproterone acetate, a 17 alpha-hydroxyprogesterone derivative [17-OHP]) on glucose and insulin metabolism. DESIGN: Seven healthy young women were investigated by using the euglycemic hyperinsulinemic glucose clamp technique (insulin delivery rate = 100 mU/kg per hour for 120 minutes). This test was performed, after an overnight fast, during the last 7 days of a spontaneous cycle and within the last 5 days of pill intake during the sixth and twelfth cycle of a continuous treatment with Diane-35 in each subject. RESULTS: The three indexes measuring the insulin-induced glucose disposal during the clamp (glucose infusion rate, glucose metabolic clearance rate, and glucose infusion rate divided by plasma insulin plateau levels) were not significantly affected by Diane-35. In contrast, the metabolic clearance rate of the exogenous insulin infused during the clamp tended to be slightly increased with Diane-35 (significant after 6 but not after 12 cycles). CONCLUSION: These results suggest that a 1-year treatment with the OC Diane-35, which contains EE2 + a 17-OHP rather than a 19-nortestosterone derivative as the progestogen compound, does not significantly alter peripheral (presumably muscular) insulin sensitivity but slightly increases insulin (presumably hepatic) clearance.
PIP: TJ: FERTILITY AND STERILITY.
http://hdl.handle.net/2268/14020

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