Article (Scientific journals)
On the use and computation of likelihood ratios in clinical chemistry.
Albert, Adelin
1982In Clinical Chemistry, 28 (5), p. 1113-9
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Keywords :
Antibodies, Monoclonal/analysis; Chemistry, Clinical/methods; Decision Making; Humans; Immunoglobulin G/analysis; Models, Biological; Multiple Sclerosis/blood/cerebrospinal fluid/diagnosis; Probability; Reference Values; Serum Albumin/analysis
Abstract :
[en] The clinical relevance of likelihood ratios (L-values) for revising the physician's diagnostic probabilities has been recognized. However, the calculation of L-values, particularly in the case of quantitative or mixed quantitative-binary test results, raises problems that have not yet been addressed. Based on a very general assumption that yields a simple functional form for the likelihood ratio, a method is developed that allows such calculations regardless of the nature and the number of clinical laboratory tests to be interpreted simultaneously. Hence the notion of predictive value (posterior probability) is extended from binary or dichotomized tests to quantitative tests, and from univariate to multivariate clinical laboratory results. The simplicity and flexibility of this approach eliminates difficulties in computation arising from the addition of new data to an existing data base. It is hoped that this method will now allow L-values to be reported along with the original test results in daily laboratory practice.
Disciplines :
General & internal medicine
Author, co-author :
Albert, Adelin  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique
Language :
English
Title :
On the use and computation of likelihood ratios in clinical chemistry.
Publication date :
1982
Journal title :
Clinical Chemistry
ISSN :
0009-9147
eISSN :
1530-8561
Publisher :
American Association for Clinical Chemistry, Washington, United States - District of Columbia
Volume :
28
Issue :
5
Pages :
1113-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 21 January 2013

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