Bone mineral density of the spine and the hip measured with dual energy X-ray absorptiometry: normal range and fracture threshold for western European (Belgian) postmenopausal females.
Bone mineral density of the spine and the hip measured with dual energy X-ray absorptiometry normal range and fracture threshold for western European (Belgian) postmenopausal females.pdf
Absorptiometry, Photon; Age Factors; Aged; Belgium; Bone Density; Female; Fractures, Spontaneous/physiopathology; Hip; Humans; Middle Aged; Osteoporosis, Postmenopausal/physiopathology; Reference Values; Sensitivity and Specificity; Spinal Injuries/physiopathology; Spine
Abstract :
[en] Bone mineral density (BMD) of the spine and the different regions of interest (ROI) of the hip were measured by dual energy X-ray absorptiometry in 278 healthy Belgian postmenopausal women and 93 postmenopausal type I osteoporotic females in order to: a) determine the normal range for lumbar and hip BMD values; b) define an "hypothetical" fracture threshold in this population; c) determine the preferential region to be considered for clinical use in type I osteoporosis. In the normal subjects, there is a negative relationship (< 0.001) between age or time elapsed since menopause (Tm) and BMD measured at the level of the spine or at the ROI of the hip. For the spine, evidence of a curvilinear relationship was assessed. Regressions of BMD at the hip as a function of age or time elapsed since menopause, were best fitted by a linear relationship. In the population of postmenopausal women who have experienced a vertebral crush fracture, no relationships were observed between spine BMD and age or Tm but the osteoporotic women had a spine BMD significantly lower compared to age-matched normal controls: Z-score = -1.2 +/- 0.6 (mean +/- SD) (p < 0.0001). Fracture threshold calculated as the 90th percentile of spine BMD measured in osteoporotic patients was 0.840 g/cm2, corresponding to the mean value -1 SD for a population of women aged 51 years.
Disciplines :
General & internal medicine
Author, co-author :
Reginster, Jean-Yves ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Janssen, C
DEROISY, Rita ; Centre Hospitalier Universitaire de Liège - CHU > Médecine de l'appareil locomoteur
Zegels, Brigitte ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Albert, Adelin ; Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique
FRANCHIMONT, Patricia ; Centre Hospitalier Universitaire de Liège - CHU > HOSPITALISATION - UROLOGIE (SN +4A)
Language :
English
Title :
Bone mineral density of the spine and the hip measured with dual energy X-ray absorptiometry: normal range and fracture threshold for western European (Belgian) postmenopausal females.
Kelly T.L., Slovik D.M., Neer R.M. (1989) Calibration and standardization of bone mineral densitometers. J Bone Miner Res 4:663-669.
Pouilles J.M., Ribot C. (1989) Que peut on attendre d'une mesure de la densité osseuse?. Rev Rhum Mal Osteoart 56:479-486.
Kanis J.A. (1990) The epidemiology of hip fracture in Europe. The ME-DOS study. Osteoporosis 1990 , C., Christiansen, K., Overgaard, Osteopress Publ, Copenhagen; 42-47.
Chesnut C.H. (1990) Osteoporosis, a world-wide problem?. Osteoporosis 1990 , C., Christiansen, K., Overgaard, Osteopress Publ., Copenhagen; 33-35.
Riggs B.L., Wahner H.W., Dunn W.L., Mazess R.B., Oxford K.P., Melton L.J. (1981) Differential changes in bone mineral density of the appendicular and axial skeleton with aging: relationship to spinal osteoporosis. J Clin Invest 67:328-335.
Kellgren J.H. (1963) Atlas of standard radiographs of arthritis. The Epidemiology of Chronic Rheumatism Vol II, Blackwell, Oxford; .
Dequeker J., Goris P., Uytterhoeven R. (1982) Osteoporosis and osteoarthritis: anthropometric distinctions. J Am Med Assoc 249:1448-1451.
Newton-John H.F., Morgan D.B. (1968) Osteoporosis: disease or senescence?. Lancet 1:232-233.
Meunier P.J., Courpron P., Edouard C., Bernard J., Bringuier J., Vignon G. (1973) Physiological senile involution and pathological rarefaction of bone: quantitative and comparative histological data. Clin Endocrinol Metab 2:239-256.
Courpron P., Meunier P., Edouard C., Bringuier J.P., Vignon G. (1973) Données histologiques quantitatives sur le vieillissement humain. Rev Rhum Mal Osteoart 40:469-483.
Krölner B., Porsnielsen S. (1982) Bone mineral content of the lumbar spine in normal and osteoporotic women. Cross-sectional and longitudinal studies. Clin Sci (Lond) 62:329-336.
Tothill P., Smith M.A., Sutton D. (1983) Dual photon absorptiometry of the spine with a low activity source of Gadolinium 153. Br J Radiol 56:829-835.
Richelson L.S., Wahner H.W., Melton L.J., Riggs B.L. (1984) Relative contributions of aging and estrogen deficiency to postmenopausal bone loss. N Engl J Med 311:1273-1275.
Sabatier J.P., Guaydier-Souquieres G., Courtheoux F., Rivaton F., Loyau G. (1985) L'absorptiométrie biphotonique rachidienne. Rev Rhum Mal Osteoart 52:685-688.
Geusens P., Dequeker J., Verstraeten A., Nijs J. (1986) Age, sex and menopause-related changes of vertebral and peripheral bone population using dual and single photon absorptiometry and radio-grammetry. J Nucl Med 27:1540-1549.
Elders P.J.M., Netelenbos J.C., Lips P., van Ginkel F.D., van der Stel T. (1988) Accelerated vertebral bone loss in relation to the menopause: a cross-sectional study on lumbar bone density in 286 women of 46 to 55 years of age. Bone Miner 5:11-19.
Gaspard U. (1987) Effets métaboliques des traitements hormonaux de la ménopause. La Ménopause , M., Lhermite, Maloine Publ., Paris; 69-94.
Braillon P., Duboeuf F., Delmas P.D., Meunier P.J. (1987) Mesure de la densité minérale osseuse lombaire par absorptiométrie biphotonique. Méthodologie. Reproductibilité. Valeurs normales. Path Biol 35:1205-1213.
Braillon P., Duboeuf F., Meary M.F., Delmas P.D., Meunier P.J. (1989) Contenu minéral osseux lombaire chez la femme. Valeurs normales obtenues par radiographie digitale quantitative. Rev Rhum Mal Osteoart 56:589-592.
Hall M.L., Heavens J., Cullum I.D., Ell P.J. (1990) The range of bone density in normal British women. Br J Radiol 63:266-269.
Duboeuf F., Braillon P., Chapuy M.C., Haond P., Hardouin C., Meary M.F., Delmas P.D., Meunier P.J. (1991) Bone mineral density of the hip measured with dualenergy X-ray absorptiometry in normal elderly women and in patients with hip fracture. Osteoporosis Int 1:242-249.
Duquesnoy B., Ythier H., Thevenon A., Cantegrit F., Tison-Muchery F., Marchandise X., Delcambre B. (1987) Appréciation par absorptiométrie biphotonique du contenu mineral osseux et détermination du seuil fracturaire dans une population de sujets de 60 à 75 ans. Rev Rhum Mal Ostéoart 54:23-30.
Schaadt O., Bohr H. (1988) Different trends of age-related diminution of bone mineral content in the lumbar spine femoral neck and femoral shaft in women. Calcif Tissue Int 42:71-76.
Riggs B.L., Melton L.J. (1986) Involutional osteoporosis. N Engl J Med 314:1676-1684.
Pocock N.A., Eisman J.A., Mazess R.B., Sambrook P.N., Yeates M.G., Freund J. (1988) Bone mineral density in Australia compared to the United States. J Bone Miner Res 3:601-604.
Sartoris J.D., Sommer F.G., Marcus R., Madvig P. (1985) Bone mineral density in the femoral neck: quantitative assessment using dual-energy projection radiography. Am J Radiol 144:605-611.
Norimatsu H., Mori S., Uesato T., Yoshikawa T., Katsuyama N. (1989) Bone mineral density of the spine and proximal femur in normal and osteoporotic subjects in Japan. Bone Miner 5:213-221.
Vega E., Mautalen C., Gomez H., Garrido A., Melo L., Sahores A.O. (1991) Bone mineral density in patients with cervical and trochanteric fractures of the proximal femur. Osteoporosis Int 1:81-86.
Pacifici R., Rupich R., Griffin M., Chines A., Susman N., Avioli L.V. (1990) Dual energy radiography versus quantitative computer tomography for the diagnosis of osteoporosis. J Clin Endocrinol Metab 70:705-710.
Ross P.D., Wasnich R.D., Heilburn L.K., Vogel J.M. (1987) Definition of a spine fracture threshold based upon prospective fracture risk. Bone 8:271-278.
Pouilles J.M., Tremollières F., Ribot C. (1990) Performances de l'absorptiométrie à rayons X dans l'ostéoporose vertébrale postménopausique. Rev Rhum Mal Osteoart 57:873-880.
Pouilles J.M., Tremollières F., Todorovsky N., Ribot C. (1991) Precision and sensitivity of dual energy X-ray absorptiometry in spinal osteoporosis. J Bone Miner Res 6:997-1002.
Madsen M. (1977) Vertebral and peripheral bone mineral content by photon absorptiometry. Invest Radiol 12:185-188.
Wilson C.R. (1977) Bone mineral content of the femoral neck and spine versus the radius and ulna. J Bone Joint Surg 59 A:665-669.
Pocock N.A., Eisman J.A., Yeates M.G., Sambrook P.N., Eberl S., Wren B.G. (1986) Limitations of forearm bone densitometry as an index of vertebral or femoral neck osteopenia. J Bone Miner Res 1:369-375.
Eastell R., Wahner H.W., O'Fallon W.M., Amadio P.C., Melton L.J., Riggs B.L. (1989) Unequal decrease in bone density of lumbar spine and ultradistal radius in Colle's and vertebral fracture syndromes. J Clin Invest 83:168-174.
Nilas L., Borg J., Gotfredsen A., Christiansen C. (1985) Comparison of single- and dual-photon absorptiometry in postmenopausal bone mineral loss. J Nucl Med 26:1257-1262.
Nilas L., Podenphant J., Riis B.J., Gotfredsen A., Christiansen C. (1987) Usefulness of regional bone measurements in patients with osteoporotic fractures of the spine and distal forearm. J Nucl Med 28:960-965.
Wasnich R.D., Ross P.D., Davis J.W., Vogel J.M. (1989) A comparison of single and multi-site BMC measurements for assessment of spine fracture probability. J Nucl Med 30:1166-1171.