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Le diabete non insulinodependant: de la physiopathologie au traitement.
Scheen, André; Lefebvre, Pierre
1996In Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique, 151 (7-9), p. 395-402; discussion 402-5
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Keywords :
Combined Modality Therapy; Diabetes Mellitus, Type 2/complications/physiopathology/therapy; Diabetic Diet; Exercise; Female; Humans; Hypoglycemic Agents/therapeutic use; Insulin/secretion; Insulin Resistance/physiology; Male
Abstract :
[en] Non-insulin-dependent (or type 2) diabetes mellitus is a common, underdiagnosed and growing disease in our society. It is responsible for increased morbidity and mortality and represents an important public health problem. This polygenic disease is often expressed late in life and its evolution is accelerated by environmental factors leading to obesity. It combines defects in both insulin secretion and insulin action, and such defects are present in various proportions according to the type of patient and the stage of the disease. Diet and physical activity recommendations are the basis of the treatment. Current pharmacological approaches aim at improving insulin secretion and/or insulin cellular action. After secondary failure to oral drugs, insulin therapy should be initiated, the patient becoming "insulin-requiring". A synergy should be searched in the combination of various therapeutic modalities in order to improve the glycaemic control.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Lefebvre, Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques
Language :
French
Title :
Le diabete non insulinodependant: de la physiopathologie au traitement.
Alternative titles :
[fr] Non-insulin-dependent diabetes: from physiopathology to treatment
Publication date :
1996
Journal title :
Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique
ISSN :
0377-8231
Publisher :
Académie Royale de Médecine de Belgique, Bruxelles, Belgium
Volume :
151
Issue :
7-9
Pages :
395-402; discussion 402-5
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 05 June 2009

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