|Reference : Occult genital herpes presenting as an endometrial infection detected at delivery: a ...|
|Scientific journals : Article|
|Human health sciences : Dermatology|
|Occult genital herpes presenting as an endometrial infection detected at delivery: a report of two cases|
|Aghazarian, Saro [Centre Hospitalier Universitaire de Liège - CHU >]|
|Nikkels, Arjen [Université de Liège - ULg > > Dermatologie >]|
|Grodos, Jacques [Hospital of Eupen > Department of Pathology >]|
|Billet, Paul [Hospital of St. Vith > Department of Gynecology >]|
|Thiry, Albert [Université de Liège - ULg > > Anatomie pathologique >]|
|Pierard, Gérald [Université de Liège - ULg > > Dermatopathologie >]|
|Boniver, Jacques [Université de Liège - ULg > > Anatomie pathologique >]|
|Delvenne, Philippe [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]|
|Journal of the European Academy of Dermatology & Venereology|
|Yes (verified by ORBi)|
|[en] Herpes simplex virus ; Genital herpes ; Pregnancy|
|[en] Background: The prevalence and clinical implications of asymptomatic genital herpes remain elusive.
Objective/aim: We report two cases of clinically asymptomatic intrautcrine herpes simplex virus II (HSV-II) infection in
order to discuss their pathological significance and demonstrate the potential utility of specific DNA probes and antibodies.
Methods: Standard histology, immunohistochemistry (IHC) and in situ hybridization (ISH) were applied to formalin-tixed.
paraffin-em bedded lissue sections of curettage specimens from women presenting deciditalised fragments retention after
Results: Hisiological analysis revealed a focal clearing of endometrial epithelial cell nuclei, suggesting a viral etiology. ISH
and IHC with differetit DNA probes or antibodies confirmed the diagnosis of HSV-II infection at the time of specimen
collection. Clinical signs of muco-cutaneous involvement in the mothers and of neonatal HSV infection were not observed.
Conclusion: These findings suggest that intrauterinc HSV-II infection is not always associated with disease. The IHC and
ISH methods can be helpful to a.ssess the diagnosis of HSV-II intrauterine infections in the presence of optically clear
cndotTietrial nuclei. Whether or not such HSV-II occult infection may be associated with viral shedding and risk of sexual
transtnission was not evaluated in the present study. © 1997 Elsevier Science B.V.
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