ORBi: Aghazarian Saro - Occult genital herpes presenting as an endometrial infection detected at delivery: a report of two cases

Reference : Occult genital herpes presenting as an endometrial infection detected at delivery: a rep...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Dermatology
	To cite this reference:	http://hdl.handle.net/2268/13964

Title :	Occult genital herpes presenting as an endometrial infection detected at delivery: a report of two cases
Language :	English
Author, co-author :	Aghazarian, Saro [Centre Hospitalier Universitaire de Liège - CHU >]
	Nikkels, Arjen [Université de Liège - ULg > > Dermatologie >]
	Grodos, Jacques [Hospital of Eupen > Department of Pathology >]
	Billet, Paul [Hospital of St. Vith > Department of Gynecology >]
	Thiry, Albert [Université de Liège - ULg > > Anatomie pathologique >]
	Pierard, Gérald [Université de Liège - ULg > > Dermatopathologie >]
	Boniver, Jacques [Université de Liège - ULg > > Anatomie pathologique >]
	Delvenne, Philippe [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Publication date :	1997
Journal title :	Journal of the European Academy of Dermatology & Venereology
Publisher :	Blackwell Publishing
Volume :	9
Pages :	276-282
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0926-9959
e-ISSN :	1468-3083
City :	Oxford
Country :	United Kingdom
Keywords :	[en] Herpes simplex virus ; Genital herpes ; Pregnancy
Abstract :	[en] Background: The prevalence and clinical implications of asymptomatic genital herpes remain elusive. Objective/aim: We report two cases of clinically asymptomatic intrautcrine herpes simplex virus II (HSV-II) infection in order to discuss their pathological significance and demonstrate the potential utility of specific DNA probes and antibodies. Methods: Standard histology, immunohistochemistry (IHC) and in situ hybridization (ISH) were applied to formalin-tixed. paraffin-em bedded lissue sections of curettage specimens from women presenting deciditalised fragments retention after normal delivery. Results: Hisiological analysis revealed a focal clearing of endometrial epithelial cell nuclei, suggesting a viral etiology. ISH and IHC with differetit DNA probes or antibodies confirmed the diagnosis of HSV-II infection at the time of specimen collection. Clinical signs of muco-cutaneous involvement in the mothers and of neonatal HSV infection were not observed. Conclusion: These findings suggest that intrauterinc HSV-II infection is not always associated with disease. The IHC and ISH methods can be helpful to a.ssess the diagnosis of HSV-II intrauterine infections in the presence of optically clear cndotTietrial nuclei. Whether or not such HSV-II occult infection may be associated with viral shedding and risk of sexual transtnission was not evaluated in the present study. © 1997 Elsevier Science B.V.
Permalink :	http://hdl.handle.net/2268/13964

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