Article (Scientific journals)
Dynamic changes in brain aromatase activity following sexual interactions in males: Where, when and why?
de Bournonville, Catherine; Dickens, Molly J.; Ball, Gregory F. et al.
2013In Psychoneuroendocrinology, 38 (6), p. 789-99
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Abstract :
[en] It is increasingly recognized that estrogens produce rapid and transient effects at many neural sites ultimately impacting physiological and behavioral endpoints. The ability of estrogens to acutely regulate cellular processes implies that their concentration should also be rapidly fine-tuned. Accordingly, rapid changes in the catalytic activity of aromatase, the limiting enzyme for estrogen synthesis, have been identified that could serve as a regulatory mechanism of local estrogen concentrations. However, the precise anatomical localization, time-course, triggering stimuli and functional significance of these enzymatic changes in vivo are not well understood. To address these issues as to where, when and why aromatase activity (AA) rapidly changes after sexual interactions, AA was assayed in six populations of aromatase-expressing cells microdissected from the brain of male quail that experienced varying durations of visual exposure to or copulation with a female. Sexual interactions resulted in a rapid AA inhibition. This inhibition occurred in specific brain regions (including the medial preoptic nucleus), in a context-dependent fashion and time-scale suggestive of post-translational modifications of the enzyme. Interestingly, the enzymatic fluctuations occurring in the preoptic area followed rather than preceded copulation and were tied specifically to the female's presence. This pattern of enzymatic changes suggests that rapid estrogen effects are important during the motivational phase of the behavior to trigger physiological events essential to activate mate search and copulation.
Research center :
Giga-Neurosciences - ULiège
Disciplines :
Neurosciences & behavior
Author, co-author :
de Bournonville, Catherine ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau
Dickens, Molly J.
Ball, Gregory F.
Balthazart, Jacques  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau
Cornil, Charlotte  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau
Language :
English
Title :
Dynamic changes in brain aromatase activity following sexual interactions in males: Where, when and why?
Publication date :
2013
Journal title :
Psychoneuroendocrinology
ISSN :
0306-4530
eISSN :
1873-3360
Publisher :
Pergamon Press (part of Elsevier Science), Oxford, United Kingdom
Volume :
38
Issue :
6
Pages :
789-99
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
ULg
Funders :
NIH - National Institutes of Health [US-MD] [US-MD]
ULiège FSR - Université de Liège. Fonds spéciaux pour la recherche [BE]
NSF - National Science Foundation [US-VA] [US-VA]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
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since 17 January 2013

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