No full text
Unpublished conference/Abstract (Scientific congresses and symposiums)
Reprogramming of replication origin firing and checkpoint adaptation in adult T cell leukemia
Barez, Pierre-Yves; Carpentier, Alexandre; Willems, Luc
2012GIGA-Cancer Seminar
 

Files


Full Text
No document available.

Send to



Details



Abstract :
[en] Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that infects about twenty million individuals worldwide. HTLV-1 is the causative agent of different diseases among which the most common are the adult T-cell leukemia (ATL) and a neurodegenerative disorder called HAM/TSP (Human associated myelopathy/ Tropical spastic paraparesis). A key parameter of HTLV-1 pathogenesis is faster replication of provirus-carrying lymphocytes allowing clonal expansion of infected cell populations. The virally-encoded Tax oncoprotein plays an essential role in this process by interacting with DNA replication origins and accelerating S phase progression. By reprogramming the timing of origin firing, Tax also creates a replicative stress leading to DNA double strand breaks. This mechanism further triggers the DNA damage response (DDR) that induces cell cycle arrest and initiates either apoptosis or senescence. However, HTLV-1 infected cells have developed strategies to interfere with the DDR and are adapted to checkpoint control. These cells are thus able to proliferate despite occurrence of DNA damage. Based on these observations, we now propose a novel therapeutic approach based on the principle of synthetic lethality.
Disciplines :
Oncology
Author, co-author :
Barez, Pierre-Yves ;  Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
Carpentier, Alexandre ;  Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
Willems, Luc  ;  Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
Language :
English
Title :
Reprogramming of replication origin firing and checkpoint adaptation in adult T cell leukemia
Publication date :
14 December 2012
Event name :
GIGA-Cancer Seminar
Event organizer :
Université de Liège - Ecole Doctorale Thématique en Cancérologie Expérimentale & GIGA Cancer
Event place :
Liège, Belgium
Event date :
14 Décembre 2012
Available on ORBi :
since 16 January 2013

Statistics


Number of views
56 (2 by ULiège)
Number of downloads
0 (0 by ULiège)

Bibliography


Similar publications



Contact ORBi