New trends in anti-malarial agents

[en] Malaria is the major parasitic infection in many tropical and subtropical regions, leading to more than one million deaths (principally young African children) out of 400 million cases each year (WHO world health report 2000). More than half of the world's population live in areas where they remain at risk of malaria infection. During last years, the situation has worsened in many ways, mainly due to malarial parasites becoming increasingly resistant to several antimalarial drugs. Furthermore, the control of malaria is becoming more complicated by the parallel spread of resistance of the mosquito vector to currently available insecticides. Discovering new drugs in this field is therefore a health priority. Several new molecules are under investigation. This review describes the classical treatments of malaria and the latest discoveries in antimalarial agents, especially artemisinin and its recent derivatives as well as the novel peroxidic compounds.

Disciplines :

Chemistry
Pharmacy, pharmacology & toxicology
Biochemistry, biophysics & molecular biology

Author, co-author :

Frederich, Michel ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie

Dogné, Jean-Michel ; Université de Liège - ULiège > Département de pharmacie > Département de pharmacie

Angenot, Luc ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie

De Mol, Patrick ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale

Language :

English

Title :

New trends in anti-malarial agents

Publication date :

August 2002

Journal title :

Current Medicinal Chemistry

ISSN :

0929-8673

eISSN :

1875-533X

Publisher :

Bentham Science Publ Ltd, Hilversum, Netherlands

Volume :

Issue :

Pages :

1435-1456

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 June 2009

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