Main Glucosidase Conversion Products of the Gluco-Alkaloids Dolichantoside and Palicoside

[en] The enzymatic glucose cleavage of palicoside revealed the biosynthetic pathway to akagerine, whereas the conversion of dolichantoside led to a new quaternary heteroyohimbine alkaloid named N(b)-methyl-21-beta-hydroxy-mayumbine. The hypothetical models of reactions occurring after the conversion of both substrates are proposed. Dolichantoside and palicoside, as well as Strychnos mellodora stem bark crude ethanol extract, exhibit significant antimycotic activity against human pathogens in presence of specific glucosidase.

Disciplines :

Phytobiology (plant sciences, forestry, mycology...)
Pharmacy, pharmacology & toxicology

Author, co-author :

Brandt, V.

Tits, Monique ; Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie

Penelle, J.

Frederich, Michel ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie

Angenot, Luc ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie

Language :

English

Title :

Main Glucosidase Conversion Products of the Gluco-Alkaloids Dolichantoside and Palicoside

Publication date :

July 2001

Journal title :

Phytochemistry

ISSN :

0031-9422

eISSN :

1873-3700

Publisher :

Elsevier, Netherlands

Volume :

Issue :

Pages :

653-9

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 June 2009

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Bibliography

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