ORBi: Frederich Michel - Strychnogucines a and B, Two New Antiplasmodial Bisindole Alkaloids from Strychnos Icaja

Reference : Strychnogucines a and B, Two New Antiplasmodial Bisindole Alkaloids from Strychnos Icaja


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Immunology & infectious disease Life sciences : Phytobiology (plant sciences, forestry, mycology...) Human health sciences : Pharmacy, pharmacology & toxicology
	To cite this reference:	http://hdl.handle.net/2268/13887

Title :	Strychnogucines a and B, Two New Antiplasmodial Bisindole Alkaloids from Strychnos Icaja
Language :	English
Author, co-author :	Frederich, Michel [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
	Gillet, Marie-Claire [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie - Département des sciences biomédicales et précliniques >]
	Prosperi, Christelle [Université de Liège - ULg > Département de physique > Département de physique >]
	Tits, Monique [Université de Liège - ULg > Département de pharmacie > Phytochimie et phytothérapie >]
	Brandt, V. [> > > >]
	Penelle, J. [> > > >]
	Hayette, Marie-Pierre [Centre Hospitalier Universitaire de Liège - CHU > > Microbiologie médicale >]
	De Mol, Patrick [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale]
	Angenot, Luc [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Publication date :	Jan-2001
Journal title :	Journal of Natural Products
Volume :	64
Issue/season :	1
Pages :	12-16
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0163-3864
e-ISSN :	1520-6025
Abstract :	[en] A reinvestigation of Strychnos icaja roots has resulted in the isolation of two tertiary quasi-symmetric bisindole alkaloids named strychnogucines A (1) and B (2). Their structures were identified by means of spectroscopic data interpretation. Compound 2 was highly active in vitro and compound 1 moderately active against four strains of Plasmodium falciparum. Strychnogucine B (2) was more active against a chloroquine-resistant strain than against a chloroquine-sensitive one (best CI(50), 80 nM against the W2 strain). In addition, this compound showed a selective antiplasmodial activity with 25-180 times greater toxicity toward P. falciparum, relative to cultured human cancer cells (KB) or human fibroblasts (WI38).
Permalink :	http://hdl.handle.net/2268/13887

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