Reference : Strychnogucines a and B, Two New Antiplasmodial Bisindole Alkaloids from Strychnos Icaja
Scientific journals : Article
Life sciences : Phytobiology (plant sciences, forestry, mycology...)
Human health sciences : Immunology & infectious disease
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/13887
Strychnogucines a and B, Two New Antiplasmodial Bisindole Alkaloids from Strychnos Icaja
English
Frederich, Michel mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Gillet, Marie-Claire mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie - Département des sciences biomédicales et précliniques >]
Prosperi, Christelle mailto [Université de Liège - ULg > Département de physique > Département de physique >]
Tits, Monique mailto [Université de Liège - ULg > Département de pharmacie > Phytochimie et phytothérapie >]
Brandt, V. [> > > >]
Penelle, J. [> > > >]
Hayette, Marie-Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Microbiologie médicale >]
De Mol, Patrick mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale]
Angenot, Luc mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Jan-2001
Journal of Natural Products
64
1
12-16
Yes (verified by ORBi)
International
0163-3864
1520-6025
[en] A reinvestigation of Strychnos icaja roots has resulted in the isolation of two tertiary quasi-symmetric bisindole alkaloids named strychnogucines A (1) and B (2). Their structures were identified by means of spectroscopic data interpretation. Compound 2 was highly active in vitro and compound 1 moderately active against four strains of Plasmodium falciparum. Strychnogucine B (2) was more active against a chloroquine-resistant strain than against a chloroquine-sensitive one (best CI(50), 80 nM against the W2 strain). In addition, this compound showed a selective antiplasmodial activity with 25-180 times greater toxicity toward P. falciparum, relative to cultured human cancer cells (KB) or human fibroblasts (WI38).
http://hdl.handle.net/2268/13887

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