Poster (Scientific congresses and symposiums) Development of original 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas as thromboxane A2 receptor antagonists
Bambi Nyanguile, Sylvie-Mireille ; Hanson, Julien ; Dogné, Jean-Michel et al.
2012 • 19th EuroQSAR
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Keywords :
Thromboxane receptor antagonists; antiplatelet agents; 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas
Abstract :
[en] A series of novel 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas were synthesized.
The newly synthesized compounds were tested in vitro and ex vivo as thromboxane A2 receptor antagonists.
Some of the test compounds showed potent thromboxane A2 receptor antagonist activity.
Three compounds (7h, 8h and 8e) were identified as leads for further pharmacological and toxicological studies.
Research center :
LABORATOIRE DE CHIMIE PHARMACEUTIQUE
Disciplines :
Pharmacy, pharmacology & toxicology
Hanson, Julien ;
Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique Dogné, Jean-Michel
Pirotte, Bernard ;
Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique Title :
Development of original 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas as thromboxane A2 receptor antagonists
Publication date :
August 2012
Event name :
19th EuroQSAR
Event organizer :
UNIVERSITY OF VIENNA
Event place :
VIENNE, Austria
Event date :
DU 26-30 AOUT 2012
Name of the research project :
DEVELOPPEMENT DE NOUVELLES BENZENES SULFONYLUREES DIVERSEMENTS SUBSTITUEES EN TANT QU ANTAGONISTES DES RECEPTEURS AU THROMBOXANE A2
Funders :
CTB - Coopération Technique Belge [BE]
Available on ORBi :
since 08 January 2013
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