Article (Scientific journals)
Metabolic activity in external and internal awareness networks in severely brain-damaged patients.
Thibaut, Aurore; Bruno, Marie-Aurélie; Chatelle, Camille et al.
2012In Journal of Rehabilitation Medicine, 44 (6), p. 487-94
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Keywords :
vegetative state; minimallys conscious state; positron emission tomography; consciousness; self-awareness; traumatic brain injury
Abstract :
[en] OBJECTIVE: An extrinsic cerebral network (encompassing lateral frontoparietal cortices) related to external/sensory awareness and an intrinsic midline network related to internal/self-awareness have been identified recently. This study measured brain metabolism in both networks in patients with severe brain damage. DESIGN: Prospective [18F]-fluorodeoxyglucose-positron emission tomography and Coma Recovery Scale-Revised assessments in a university hospital setting. SUBJECTS: Healthy volunteers and patients in vegetative state/unresponsive wakefulness syndrome (VS/UWS), minimally conscious state (MCS), emergence from MCS (EMCS), and locked-in syndrome (LIS). RESULTS: A total of 70 patients were included in the study: 24 VS/UWS, 28 MCS, 10 EMCS, 8 LIS and 39 age-matched controls. VS/UWS showed metabolic dysfunction in extrinsic and intrinsic networks and thalami. MCS showed dysfunction mostly in intrinsic network and thalami. EMCS showed impairment in posterior cingulate/retrosplenial cortices. LIS showed dysfunction only in infratentorial regions. Coma Recovery Scale-Revised total scores correlated with metabolic activity in both extrinsic and part of the intrinsic network and thalami. CONCLUSION: Progressive recovery of extrinsic and intrinsic awareness network activity was observed in severely brain-damaged patients, ranging from VS/UWS, MCS, EMCS to LIS. The predominance of intrinsic network impairment in MCS could reflect altered internal/self-awareness in these patients, which is difficult to quantify at the bedside.
Research center :
Coma Science Group
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurology
Author, co-author :
Thibaut, Aurore ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Bruno, Marie-Aurélie ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Chatelle, Camille ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Gosseries, Olivia  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Vanhaudenhuyse, Audrey  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Demertzi, Athina  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Schnakers, Caroline ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Thonnard, Marie ;  Université de Liège - ULiège > Centre de recherches du cyclotron
CHARLAND-VERVILLE, Vanessa 
BERNARD, Claire ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine nucléaire
Bahri, Mohamed Ali  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Phillips, Christophe  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Boly, Mélanie ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Hustinx, Roland  ;  Université de Liège - ULiège > Département des sciences cliniques > Médecine nucléaire
Laureys, Steven  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
More authors (5 more) Less
Language :
English
Title :
Metabolic activity in external and internal awareness networks in severely brain-damaged patients.
Publication date :
2012
Journal title :
Journal of Rehabilitation Medicine
ISSN :
1650-1977
eISSN :
1651-2081
Publisher :
Taylor & Francis, Sweden
Volume :
44
Issue :
6
Pages :
487-94
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 12 January 2012

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