Article (Scientific journals)
Auditory resting-state network connectivity in tinnitus: a functional MRI study.
MAUDOUX, Audrey; Lefèbvre, Philippe; CABAY, Jean-Evrard et al.
2012In PLoS ONE, 7 (5), p. 36222
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Keywords :
Adult; Aged; Basal Metabolism; Brain/metabolism/pathology/physiology/physiopathology; Case-Control Studies; Chronic Disease; Female; Hearing/physiology; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Net/metabolism/pathology/physiology/physiopathology; Tinnitus/diagnosis/metabolism/pathology/physiopathology; Young Adult
Abstract :
[en] The underlying functional neuroanatomy of tinnitus remains poorly understood. Few studies have focused on functional cerebral connectivity changes in tinnitus patients. The aim of this study was to test if functional MRI "resting-state" connectivity patterns in auditory network differ between tinnitus patients and normal controls. Thirteen chronic tinnitus subjects and fifteen age-matched healthy controls were studied on a 3 tesla MRI. Connectivity was investigated using independent component analysis and an automated component selection approach taking into account the spatial and temporal properties of each component. Connectivity in extra-auditory regions such as brainstem, basal ganglia/NAc, cerebellum, parahippocampal, right prefrontal, parietal, and sensorimotor areas was found to be increased in tinnitus subjects. The right primary auditory cortex, left prefrontal, left fusiform gyrus, and bilateral occipital regions showed a decreased connectivity in tinnitus. These results show that there is a modification of cortical and subcortical functional connectivity in tinnitus encompassing attentional, mnemonic, and emotional networks. Our data corroborate the hypothesized implication of non-auditory regions in tinnitus physiopathology and suggest that various regions of the brain seem involved in the persistent awareness of the phenomenon as well as in the development of the associated distress leading to disabling chronic tinnitus.
Disciplines :
Otolaryngology
Author, co-author :
MAUDOUX, Audrey 
Lefèbvre, Philippe ;  Université de Liège - ULiège > Département des sciences cliniques > Oto-rhino-laryngologie et audiophonologie
CABAY, Jean-Evrard ;  Centre Hospitalier Universitaire de Liège - CHU > Département de Physique Médicale > Service médical de médecine nucléaire et imagerie onco
Demertzi, Athina  ;  Université de Liège > Centre de recherches du cyclotron
Vanhaudenhuyse, Audrey  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Laureys, Steven  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Soddu, Andrea ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Language :
English
Title :
Auditory resting-state network connectivity in tinnitus: a functional MRI study.
Publication date :
2012
Journal title :
PLoS ONE
eISSN :
1932-6203
Publisher :
Public Library of Science, United States - California
Volume :
7
Issue :
5
Pages :
e36222
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 07 January 2013

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