Article (Scientific journals)
Resting state networks and consciousness Alterations of multiple resting state network connectivity in physiological, pharmacological and pathological consciousness states
Heine, Lizette; Soddu, Andrea; Gomez, Francisco et al.
2012In Frontiers in Psychology, 3, p. 295
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Keywords :
default mode network; resting state networks; consciousness; sleep; anesthesia; coma; hypnosis
Abstract :
[en] In order to better understand the functional contribution of resting state activity to conscious cognition, we aimed to review increases and decreases in fMRI functional connectivity under physiological (sleep), pharmacological (anesthesia) and pathological altered states of consciousness, such as brain death, coma, vegetative state/unresponsive wakefulness syndrome, and minimally conscious state. The reviewed RSNs were the DMN, left and right executive control, salience, sensorimotor, auditory and visual networks. We highlight some methodological issues concerning resting state analyses in severely injured brains mainly in terms of hypothesis-driven seed-based correlation analysis and data-driven independent components analysis approaches. Finally, we attempt to contextualize our discussion within theoretical frameworks of conscious processes. We think that this “lesion” approach allows us to better determine the necessary conditions under which normal conscious cognition takes place. At the clinical level, we acknowledge the technical merits of the resting state paradigm. Indeed, fast and easy acquisitions are preferable to activation paradigms in clinical populations. Finally, we emphasize the need to validate the diagnostic and prognostic value of fMRI resting state measurements in non-communicating brain damaged patients.
Disciplines :
Neurosciences & behavior
Neurology
Author, co-author :
Heine, Lizette ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Soddu, Andrea ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Gomez, Francisco
Vanhaudenhuyse, Audrey  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
TSHIBANDA, Luaba ;  Centre Hospitalier Universitaire de Liège - CHU > Radiodiagnostic
Thonnard, Marie ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Charland-Verville, Vanessa ;  Université de Liège - ULiège > Centre de recherches du cyclotron
KIRSCH, Murielle ;  Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
Laureys, Steven  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Demertzi, Athina  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Language :
English
Title :
Resting state networks and consciousness Alterations of multiple resting state network connectivity in physiological, pharmacological and pathological consciousness states
Publication date :
2012
Journal title :
Frontiers in Psychology
eISSN :
1664-1078
Publisher :
Switzerland Frontiers Research Foundation, Pully, Switzerland
Volume :
3
Pages :
295
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 07 January 2013

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