The role of activated neutrophils in the early stage of equine laminitis.

Animals; Foot Diseases/physiopathology/veterinary; Horse Diseases/physiopathology; Horses; Inflammation/physiopathology/veterinary; Neutrophil Activation/physiology; Neutrophil Infiltration/physiology

Abstract :

[en] Despite ongoing research and a widening range of treatment options, laminitis remains a severely damaging condition with poorly understood pathophysiology. Results obtained from cytokine regulation studies during the last decade have highlighted the inflammatory nature of laminitis. This review will describe the role of systemic activation and local infiltration of neutrophils in laminar tissues in the induction of laminitis. Particular emphasis is placed on the role of neutrophil activation in subsequent vascular dysfunction and oxidative and proteolysis imbalances that are pathways previously implicated in laminitis. Neutrophils, by the way of their interdependent relationship with endothelial cells and keratinocytes, dramatically increase the inflammatory response culminating in the failure of the laminar dermal-epidermal interface.

Research center :

CORD - Centre de l'Oxygène, Recherche et Développement - ULiège

Disciplines :

Veterinary medicine & animal health

Author, co-author :

de la Rebière de Pouyade, Geoffroy ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux

Serteyn, Didier ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux

Language :

English

Title :

The role of activated neutrophils in the early stage of equine laminitis.

Publication date :

2011

Journal title :

Veterinary Journal

ISSN :

1090-0233

eISSN :

1532-2971

Publisher :

Elsevier, London, United Kingdom

Volume :

189

Issue :

Pages :

27-33

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 29 December 2012

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72 (13 by ULiège)

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5 (2 by ULiège)

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