Article (Scientific journals)
Tumeur neuroendocrine de la cavite nasale (esthesioneuroblastome). A propos d'un cas avec syndrome de Cushing paraneoplasique.
Reznik, Michel; Melon, J.; Lambricht, M. et al.
1987In Annales de Pathologie, 7 (2), p. 137-42
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Keywords :
ACTH Syndrome, Ectopic/etiology; Female; Humans; Middle Aged; Nasal Cavity/pathology; Neoplasm Proteins/analysis; Neuroectodermal Tumors, Primitive, Peripheral/analysis/pathology/secretion; Nose Neoplasms/analysis/pathology/secretion; Olfactory Mucosa/analysis/pathology/secretion; Paraneoplastic Endocrine Syndromes/etiology; Pituitary Gland/pathology; Pituitary Hormones, Anterior/analysis; Pituitary-Adrenal System/physiopathology
Abstract :
[en] Presentation of a 48-y old woman who developed a neuroendocrine tumor of the nasal cavities. This lesion progressed rapidly despite an extensive resection and repeated chemotherapy. The patient refused radiotherapy. Before her death, 28 months later, she exhibited a paraneoplastic Cushing-like syndrome. At autopsy, restricted to the brain, there was a 5 cm diameter tumor invading the frontal area without alteration of the hypothalamus or the pituitary gland. Routine histology and electron microscopy confirmed the neuroendocrine nature of the tumor. Immunohistochemistry revealed the tumor to be positive only for neurone specific enolase, negative for S-100 protein, neurofilament and ACTH. The pituitary gland was positive for most usual hormones (GH, PRL, TSH, LH, FSH) but only few cells were slightly positive for ACTH. Many Crooke cells were observed. These findings suggest that the tumor secreted an ACTH-like substance (not detected actually by immunochemistry) that stimulated the activity of the adrenal cortex but inhibited normal production of ACTH at the pituitary gland level.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Reznik, Michel ;  Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Melon, J.
Lambricht, M.
Kaschten, Bruno ;  Université de Liège - ULiège > Neurochirurgie
Beckers, Albert ;  Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie
Language :
French
Title :
Tumeur neuroendocrine de la cavite nasale (esthesioneuroblastome). A propos d'un cas avec syndrome de Cushing paraneoplasique.
Alternative titles :
[en] Neuroendocrine tumor of the nasal cavity (esthesioneuroblastoma). Apropos of a case with paraneoplastic Cushing's syndrome
Publication date :
1987
Journal title :
Annales de Pathologie
ISSN :
0242-6498
Publisher :
Masson, Moulineaux Cedex 9, France
Volume :
7
Issue :
2
Pages :
137-42
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 08 May 2010

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