ORBi: Ouédraogo, M - Monoolein-water liquid crystalline gels of gentamicin as bioresorbable implants for the local treatment of chronic osteomyelitis: in vitro characterization

Reference : Monoolein-water liquid crystalline gels of gentamicin as bioresorbable implants for the ...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Pharmacy, pharmacology & toxicology
	To cite this reference:	http://hdl.handle.net/2268/13631

Title :	Monoolein-water liquid crystalline gels of gentamicin as bioresorbable implants for the local treatment of chronic osteomyelitis: in vitro characterization
Language :	English
Author, co-author :	Ouédraogo, M [ > > ]
	Semdé, R [ > > ]
	Somé, I.T [ > > ]
	Traoré Ouédraogo, R [ > > ]
	Guissou, I.P [ > > ]
	Henschel, V [ > > ]
	Dubois, J [ > > ]
	Amighi, K [ > > ]
	Evrard, Brigitte [Université de Liège - ULg > Département de pharmacie > Pharmacie galénique >]
Publication date :	2008
Journal title :	Drug Development & Industrial Pharmacy
Publisher :	Taylor & Francis
Volume :	34
Pages :	753-760
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0363-9045
e-ISSN :	1520-5762
City :	Philadelphia
Country :	PA
Abstract :	[en] To maximize the efficacy of chronic osteomyelitis antibiotherapy while reducing antibiotic systemic toxicity, as well as time and costs of hospitalizations, it has been thought that monoolein-water gels incorporating gentamicin sulfate could be used as local, bioresorbable,and sustained-release implants. For this purpose, four formulations were examined with regard to their physicochemical and in vitro drug release characteristics. Hot stage microscopy, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA),and X-ray diffraction showed cubic liquid crystalline and eutectic structures. The more suitable formulation consisting of 80-15-5%wt/wt monoolein-water-gentamicin sulfate progressively released the antibiotic for a period of 3 weeks without burst effect. Moreover, the content and the release profile of gentamicin sulfate were not significantly changed after storage at 2-6 degrees C for a period of 10 months.
Permalink :	http://hdl.handle.net/2268/13631

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