New models for analyzing mast cell functions in vivo.

[en] In addition to their well-accepted role as critical effector cells in anaphylaxis and other acute IgE-mediated allergic reactions, mast cells (MCs) have been implicated in a wide variety of processes that contribute to disease or help to maintain health. Although some of these roles were first suggested by analyses of MC products or functions in vitro, it is critical to determine whether, and under which circumstances, such potential roles actually can be performed by MCs in vivo. This review discusses recent advances in the development and analysis of mouse models to investigate the roles of MCs and MC-associated products during biological responses in vivo, and comments on some of the similarities and differences in the results obtained with these newer versus older models of MC deficiency.

Disciplines :

Life sciences: Multidisciplinary, general & others
Immunology & infectious disease

Author, co-author :

Marichal, Thomas ; Université de Liège - ULiège > GIGA-Research

Reber, Laurent L

Galli, Stephen J.

Language :

English

Title :

New models for analyzing mast cell functions in vivo.

Publication date :

2012

Journal title :

Trends in Immunology

ISSN :

1471-4906

eISSN :

1471-4981

Publisher :

Elsevier, Netherlands

Volume :

Issue :

Pages :

613-25

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 11 December 2012

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Bibliography

Oka, T., Evidence questioning cromolyn's effectiveness and selectivity as a 'mast cell stabilizer' in mice (2012) Lab. Invest., 92, pp. 1472-1482
Oliveira, S.H., Lukacs, N.W., Stem cell factor: a hemopoietic cytokine with important targets in asthma (2003) Curr. Drug Targets Inflamm. Allergy, 2, pp. 313-318
Reber, L., Stem cell factor and its receptor c-Kit as targets for inflammatory diseases (2006) Eur. J. Pharmacol., 533, pp. 327-340
Kitamura, Y., Heterogeneity of mast cells and phenotypic change between subpopulations (1989) Annu. Rev. Immunol., 7, pp. 59-76
Galli, S.J., Mast cells as "tunable" effector and immunoregulatory cells: recent advances (2005) Annu. Rev. Immunol., 23, pp. 749-786
Grimbaldeston, M.A., Mast cell-deficient W-sash c-kit mutant KitW-sh/W-sh mice as a model for investigating mast cell biology in vivo (2005) Am. J. Pathol., 167, pp. 835-848
Dawicki, W., Marshall, J.S., New and emerging roles for mast cells in host defence (2007) Curr. Opin. Immunol., 19, pp. 31-38
Piliponsky, A.M., Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice (2010) Am. J. Pathol., 176, pp. 926-938
Galli, S.J., Mast cells in the development of adaptive immune responses (2005) Nat. Immunol., 6, pp. 135-142
Grimbaldeston, M.A., Effector and potential immunoregulatory roles of mast cells in IgE-associated acquired immune responses (2006) Curr. Opin. Immunol., 18, pp. 751-760
Grimbaldeston, M.A., Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B (2007) Nat. Immunol., 8, pp. 1095-1104
Zhou, J.S., Mast cell deficiency in KitW-sh mice does not impair antibody-mediated arthritis (2007) J. Exp. Med., 204, pp. 2797-2802
Hayashi, S., Exon skipping by mutation of an authentic splice site of c-kit gene in W/W mouse (1991) Nucleic Acids Res., 19, pp. 1267-1271
Nocka, K., Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W (1990) EMBO J., 9, pp. 1805-1813
Nagle, D.L., Physical mapping of the Tec and Gabrb1 loci reveals that the Wsh mutation on mouse chromosome 5 is associated with an inversion (1995) Hum. Mol. Genet., 4, pp. 2073-2079
Nigrovic, P.A., Genetic inversion in mast cell-deficient Wsh mice interrupts corin and manifests as hematopoietic and cardiac aberrancy (2008) Am. J. Pathol., 173, pp. 1693-1701
Tsai, M., Using mast cell knock-in mice to analyze the roles of mast cells in allergic responses in vivo (2005) Chem. Immunol. Allergy, 87, pp. 179-197
Chervenick, P.A., Boggs, D.R., Decreased neutrophils and megakaryocytes in anemic mice of genotype W/Wv (1969) J. Cell. Physiol., 73, pp. 25-30
Feyerabend, T.B., Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity (2011) Immunity, 35, pp. 832-844
Lantz, C.S., Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites (1998) Nature, 392, pp. 90-93
Nakano, T., Fate of bone marrow-derived cultured mast cells after intracutaneous, intraperitoneal, and intravenous transfer into genetically mast cell-deficient W/Wv mice. Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells (1985) J. Exp. Med., 162, pp. 1025-1043
Martin, T.R., Mast cell activation enhances airway responsiveness to methacholine in the mouse (1993) J. Clin. Invest., 91, pp. 1176-1182
Tanzola, M.B., Mast cells exert effects outside the central nervous system to influence experimental allergic encephalomyelitis disease course (2003) J. Immunol., 171, pp. 4385-4391
Wolters, P.J., Tissue-selective mast cell reconstitution and differential lung gene expression in mast cell-deficient KitW-sh/KitW-sh sash mice (2005) Clin. Exp. Allergy, 35, pp. 82-88
Otsu, K., Phenotypic changes of bone marrow-derived mast cells after intraperitoneal transfer into W/Wv mice that are genetically deficient in mast cells (1987) J. Exp. Med., 165, pp. 615-627
Scholten, J., Mast cell-specific Cre/loxP-mediated recombination in vivo (2008) Transgenic Res., 17, pp. 307-315
Feyerabend, T.B., Deletion of Notch1 converts pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic mechanisms (2009) Immunity, 30, pp. 67-79
Lilla, J.N., Reduced mast cell and basophil numbers and function in Cpa3-Cre
Mcl-1fl/fl mice (2011) Blood, 118, pp. 6930-6938
Müsch, W., Generation and characterization of alpha-chymase-Cre transgenic mice (2008) Genesis, 46, pp. 163-166
Dudeck, A., Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens (2011) Immunity, 34, pp. 973-984
Voehringer, D., Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice (2008) J. Immunol., 180, pp. 4742-4753
Gordon, J.R., Galli, S.J., Phorbol 12-myristate 13-acetate-induced development of functionally active mast cells in W/Wv but not Sl/Sld genetically mast cell-deficient mice (1990) Blood, 75, pp. 1637-1645
Ando, A., Effects of chronic treatment with the c-kit ligand, stem cell factor, on immunoglobulin E-dependent anaphylaxis in mice. Genetically mast cell-deficient Sl/Sld mice acquire anaphylactic responsiveness, but the congenic normal mice do not exhibit augmented responses (1993) J. Clin. Invest., 92, pp. 1639-1649
Schmidt-Supprian, M., Rajewsky, K., Vagaries of conditional gene targeting (2007) Nat. Immunol., 8, pp. 665-668
Serafin, W.E., Carboxypeptidase A in mouse mast cells. Identification, characterization, and use as a differentiation marker (1987) J. Immunol., 139, pp. 3771-3776
Voehringer, D., Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production (2004) Immunity, 20, pp. 267-277
Taghon, T., Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3 (2007) Nat. Immunol., 8, pp. 845-855
Franco, C.B., Distinguishing mast cell and granulocyte differentiation at the single-cell level (2010) Cell Stem Cell, 6, pp. 361-368
Steimer, D.A., Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function (2009) Blood, 113, pp. 2805-2815
Zhou, P., Mcl-1 in transgenic mice promotes survival in a spectrum of hematopoietic cell types and immortalization in the myeloid lineage (1998) Blood, 92, pp. 3226-3239
Wershil, B.K., 125I-fibrin deposition in IgE-dependent immediate hypersensitivity reactions in mouse skin. Demonstration of the role of mast cells using genetically mast cell-deficient mice locally reconstituted with cultured mast cells (1987) J. Immunol., 139, pp. 2605-2614
Takeishi, T., Differences in the expression of the cardiopulmonary alterations associated with anti-immunoglobulin E-induced or active anaphylaxis in mast cell-deficient and normal mice. Mast cells are not required for the cardiopulmonary changes associated with certain fatal anaphylactic responses (1991) J. Clin. Invest., 88, pp. 598-608
Miyajima, I., Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and FcγRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis (1997) J. Clin. Invest., 99, pp. 901-914
Mukai, K., Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells (2005) Immunity, 23, pp. 191-202
Newlands, G.F., Stem cell factor contributes to intestinal mucosal mast cell hyperplasia in rats infected with Nippostrongylus brasiliensis or Trichinella spiralis, but anti-stem cell factor treatment decreases parasite egg production during N. brasiliensis infection (1995) Blood, 86, pp. 1968-1976
Brandt, E.B., Mast cells are required for experimental oral allergen-induced diarrhea (2003) J. Clin. Invest., 112, pp. 1666-1677
Gekara, N.O., Weiss, S., Mast cells initiate early anti-Listeria host defences (2008) Cell. Microbiol., 10, pp. 225-236
Czechowicz, A., Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches (2007) Science, 318, pp. 1296-1299
Buch, T., A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration (2005) Nat. Methods, 2, pp. 419-426
Sawaguchi, M., Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness (2012) J. Immunol., 188, pp. 1809-1818
Otsuka, A., Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity (2011) PLoS ONE, 6, pp. e25538
Yagi, R., Regulation of the Il4 gene is independently controlled by proximal and distal 3' enhancers in mast cells and basophils (2007) Mol. Cell. Biol., 27, pp. 8087-8097
Furumoto, Y., PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability (2011) Blood, 118, pp. 5466-5475
Gerbaulet, A., Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit (2011) Blood, 117, pp. 2012-2021
Sharma, N., SH2 domain-containing phosphatase 2 is a critical regulator of connective tissue mast cell survival and homeostasis in mice (2012) Mol. Cell. Biol., 32, pp. 2653-2663
Muzumdar, M.D., A global double-fluorescent Cre reporter mouse (2007) Genesis, 45, pp. 593-605
Haff, L.A., Improved quantitative PCR using nested primers (1994) PCR Methods Appl., 3, pp. 332-337
Galli, S.J., Hammel, I., Unequivocal delayed hypersensitivity in mast cell-deficient and beige mice (1984) Science, 226, pp. 710-713
Bryce, P.J., Immune sensitization in the skin is enhanced by antigen-independent effects of IgE (2004) Immunity, 20, pp. 381-392
Brown, M.A., Hatfield, J.K., Mast cells are important modifiers of autoimmune disease: With so much evidence, why is there still controversy? (2012) Front. Immunol., 3, p. 147
Rodewald, H.R., Feyerabend, T.B., Widespread immunological functions of mast cells: fact or fiction? (2012) Immunity, 37, pp. 13-24
Akahoshi, M., Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice (2011) J. Clin. Invest., 121, pp. 4180-4191
Gilfillan, A.M., Beaven, M.A., Regulation of mast cell responses in health and disease (2011) Crit. Rev. Immunol., 31, pp. 475-529
Ribatti, D., Crivellato, E., Mast cells, angiogenesis and cancer (2011) Adv. Exp. Med. Biol., 716, pp. 270-288
Kennelly, R., Mast cells in tissue healing: from skin to the gastrointestinal tract (2011) Curr. Pharm. Des., 17, pp. 3772-3775
Galli, S.J., Immunomodulatory mast cells: negative, as well as positive, regulators of immunity (2008) Nat. Rev. Immunol., 8, pp. 478-486
Galli, S.J., Tsai, M., IgE and mast cells in allergic disease (2012) Nat. Med., 18, pp. 693-704
Abraham, S.N., St John, A.L., Mast cell-orchestrated immunity to pathogens (2010) Nat. Rev. Immunol., 10, pp. 440-452
Supajatura, V., Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity (2002) J. Clin. Invest., 109, pp. 1351-1359
Schneider, L.A., Molecular mechanism of mast cell mediated innate defense against endothelin and snake venom sarafotoxin (2007) J. Exp. Med., 204, pp. 2629-2639
Metz, M., Mast cells can enhance resistance to snake and honeybee venoms (2006) Science, 313, pp. 526-530
Enoksson, M., Mast cells as sensors of cell injury through IL-33 recognition (2011) J. Immunol., 186, pp. 2523-2528
Lunderius-Andersson, C., Mast cells respond to cell injury through the recognition of IL-33 (2012) Front. Immunol., 3, p. 82
Schäfer, B., Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice J. Allergy Clin. Immunol, , (in press)
Fantozzi, R., Mast cell and neutrophil interactions: a role for superoxide anion and histamine (1985) Agents Actions, 16, pp. 260-264
Gri, G., CD4+CD25+ regulatory T cells suppress mast cell degranulation and allergic responses through OX40-OX40L interaction (2008) Immunity, 29, pp. 771-781
Gaudenzio, N., Cell-cell cooperation at the T helper cell/mast cell immunological synapse (2009) Blood, 114, pp. 4979-4988
Hill, P.B., Stem cell factor enhances immunoglobulin E-dependent mediator release from cultured rat bone marrow-derived mast cells: activation of previously unresponsive cells demonstrated by a novel ELISPOT assay (1996) Immunology, 87, pp. 326-333
Ito, T., Stem cell factor programs the mast cell activation phenotype (2012) J. Immunol., 188, pp. 5428-5437
Galli, S.J., The kit ligand, stem cell factor (1994) Adv. Immunol., 55, pp. 1-96
Komai-Koma, M., Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naive mice (2012) Allergy, 67, pp. 1118-1126
Okayama, Y., Expression of a functional high-affinity IgG receptor, FcγRI, on human mast cells: up-regulation by IFN-γ (2000) J. Immunol., 164, pp. 4332-4339
Baccari, G.C., Mast cells in nonmammalian vertebrates: an overview (2011) Int. Rev. Cell Mol. Biol., 290, pp. 1-53
Galli, S.J., Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils (2011) Nat. Immunol., 12, pp. 1035-1044
Bowie, M.B., Steel factor responsiveness regulates the high self-renewal phenotype of fetal hematopoietic stem cells (2007) Blood, 109, pp. 5043-5048
Ikuta, K., Weissman, I.L., Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation (1992) Proc. Natl. Acad. Sci. U.S.A., 89, pp. 1502-1506
Ogawa, M., Expression and function of c-kit in hemopoietic progenitor cells (1991) J. Exp. Med., 174, pp. 63-71
Galli, S.J., Regulation of mouse and human mast cell development, survival and function by stem cell factor, the ligand for the c-kit receptor (1995) Int. Arch. Allergy Immunol., 107, pp. 51-53
Okayama, Y., Kawakami, T., Development, migration, and survival of mast cells (2006) Immunol. Res., 34, pp. 97-115
Tsai, M., Induction of mast cell proliferation, maturation, and heparin synthesis by the rat c-kit ligand, stem cell factor (1991) Proc. Natl. Acad. Sci. U.S.A., 88, pp. 6382-6386
Tsai, M., The rat c-kit ligand, stem cell factor, induces the development of connective tissue-type and mucosal mast cells in vivo. Analysis by anatomical distribution, histochemistry, and protease phenotype (1991) J. Exp. Med., 174, pp. 125-131
Oliveira, S.H., Stem cell factor induces eosinophil activation and degranulation: mediator release and gene array analysis (2002) Blood, 100, pp. 4291-4297
Krishnamoorthy, N., Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma (2008) Nat. Med., 14, pp. 565-573
Heinemann, A., Stem cell factor stimulates the chemotaxis, integrin upregulation, and survival of human basophils (2005) J. Allergy Clin. Immunol., 116, pp. 820-826
Manova, K., Gonadal expression of c-kit encoded at the W locus of the mouse (1990) Development, 110, pp. 1057-1069
Manova, K., Bachvarova, R.F., Expression of c-kit encoded at the W locus of mice in developing embryonic germ cells and presumptive melanoblasts (1991) Dev. Biol., 146, pp. 312-324
Huizinga, J.D., W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity (1995) Nature, 373, pp. 347-349
Milenkovic, N., Nociceptive tuning by stem cell factor/c-Kit signaling (2007) Neuron, 56, pp. 893-906
Takagi, K., Involvement of stem cell factor and its receptor tyrosine kinase c-kit in pain regulation (2008) Neuroscience, 153, pp. 1278-1288
Peters, E.M., KIT is expressed by epithelial cells in vivo (2003) J. Invest. Dermatol., 121, pp. 976-984
Stokman, G., Stem cell factor expression after renal ischemia promotes tubular epithelial survival (2010) PLoS ONE, 5, pp. e14386
Cozzi, E., The naive airway hyperresponsiveness of the A/J mouse is KIT-mediated (2011) Proc. Natl. Acad. Sci. U.S.A., 108, pp. 12787-12792
Wiener, Z., Highly reduced peritoneal mast cell number and decreased c-kit expression in histidine decarboxylase knock out mice (2001) Inflamm. Res., 50 (SUPPL 2), pp. S55-S56
Ohtsu, H., Mice lacking histidine decarboxylase exhibit abnormal mast cells (2001) FEBS Lett., 502, pp. 53-56
Wastling, J.M., Histochemical and ultrastructural modification of mucosal mast cell granules in parasitized mice lacking the β-chymase, mouse mast cell protease-1 (1998) Am. J. Pathol., 153, pp. 491-504
Younan, G., The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5 (2010) J. Immunol., 185, pp. 7681-7690
Tchougounova, E., The chymase, mouse mast cell protease 4, constitutes the major chymotrypsin-like activity in peritoneum and ear tissue. A role for mouse mast cell protease 4 in thrombin regulation and fibronectin turnover (2003) J. Exp. Med., 198, pp. 423-431
Stevens, R.L., Transgenic mice that possess a disrupted mast cell protease 5 (mMCP-5) gene can not store carboxypeptidase A (mMC-CPA) protein in their granules (1996) FASEB J., 10, p. 17772
Abonia, J.P., Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle (2005) J. Immunol., 174, pp. 7285-7291
Thakurdas, S.M., The mast cell-restricted tryptase mMCP-6 has a critical immunoprotective role in bacterial infections (2007) J. Biol. Chem., 282, pp. 20809-20815
Shin, K., Mouse mast cell tryptase mMCP-6 is a critical link between adaptive and innate immunity in the chronic phase of trichinella spiralis infection (2008) J. Immunol., 180, pp. 4885-4891
Hunt, J.E., Natural disruption of the mouse mast cell protease 7 gene in the C57BL/6 mouse (1996) J. Biol. Chem., 271, pp. 2851-2855
Feyerabend, T.B., Loss of histochemical identity in mast cells lacking carboxypeptidase A (2005) Mol. Cell. Biol., 25, pp. 6199-6210
Humphries, D.E., Heparin is essential for the storage of specific granule proteases in mast cells (1999) Nature, 400, pp. 769-772
Forsberg, E., Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme (1999) Nature, 400, pp. 773-776
Kung, T.T., Mast cells modulate allergic pulmonary eosinophilia in mice (1995) Am. J. Respir. Cell Mol. Biol., 12, pp. 404-409
Takeda, K., Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice (1997) J. Exp. Med., 186, pp. 449-454
Kobayashi, T., An essential role of mast cells in the development of airway hyperresponsiveness in a murine asthma model (2000) J. Immunol., 164, pp. 3855-3861
Williams, C.M., Galli, S.J., Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice (2000) J. Exp. Med., 192, pp. 455-462
Yu, M., Mast cells can promote the development of multiple features of chronic asthma in mice (2006) J. Clin. Invest., 116, pp. 1633-1641
Nakae, S., Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and TH2 cytokine production in an asthma model in mice (2007) J. Allergy Clin. Immunol., 120, pp. 48-55
Becker, M., Genetic variation determines mast cell functions in experimental asthma (2011) J. Immunol., 186, pp. 7225-7231
Lee, D.M., Mast cells: a cellular link between autoantibodies and inflammatory arthritis (2002) Science, 297, pp. 1689-1692
Elliott, E.R., Deletion of Syk in neutrophils prevents immune complex arthritis (2011) J. Immunol., 187, pp. 4319-4330
Mancardi, D.A., Cutting edge: the murine high-affinity IgG receptor FcγRIV is sufficient for autoantibody-induced arthritis (2011) J. Immunol., 186, pp. 1899-1903
Secor, V.H., Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis (2000) J. Exp. Med., 191, pp. 813-822
Bennett, J.L., Bone marrow-derived mast cells accumulate in the central nervous system during inflammation but are dispensable for experimental autoimmune encephalomyelitis pathogenesis (2009) J. Immunol., 182, pp. 5507-5514
Li, H., Kit(W-sh) mice develop earlier and more severe experimental autoimmune encephalomyelitis due to absence of immune suppression (2011) J. Immunol., 187, pp. 274-282
Piconese, S., Exacerbated experimental autoimmune encephalomyelitis in mast-cell-deficient KitW-sh/W-sh mice (2011) Lab. Invest., 91, pp. 627-641
Askenase, P.W., Defective elicitation of delayed-type hypersensitivity in W/Wv and Sl/Sld mast cell-deficient mice (1983) J. Immunol., 131, pp. 2687-2694
Biedermann, T., Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2 (2000) J. Exp. Med., 192, pp. 1441-1452
Norman, M.U., Mast cells regulate the magnitude and the cytokine microenvironment of the contact hypersensitivity response (2008) Am. J. Pathol., 172, pp. 1638-1649
Abt, M.C., Artis, D., The intestinal microbiota in health and disease: the influence of microbial products on immune cell homeostasis (2009) Curr. Opin. Gastroenterol., 25, pp. 496-502
Abt, M.C., Commensal bacteria calibrate the activation threshold of innate antiviral immunity (2012) Immunity, 37, pp. 158-170
Hill, D.A., Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation (2012) Nat. Med., 18, pp. 538-546
Finkelman, F.D., Anaphylaxis: lessons from mouse models (2007) J. Allergy Clin. Immunol., 120, pp. 506-517
Nigrovic, P.A., Lee, D.M., Synovial mast cells: role in acute and chronic arthritis (2007) Immunol. Rev., 217, pp. 19-37
Mekori, Y.A., Galli, S.J., Undiminished immunologic tolerance to contact sensitivity in mast cell-deficient W/Wv and Sl/Sld mice (1985) J. Immunol., 135, pp. 879-885
Mekori, Y.A., Studies of the role of mast cells in contact sensitivity responses. Passive transfer of the reaction into mast cell-deficient mice locally reconstituted with cultured mast cells: effect of reserpine on transfer of the reaction with DNP-specific cloned T cells (1987) Cell. Immunol., 109, pp. 39-52
Yu, M., Identification of an IFN-γ/mast cell axis in a mouse model of chronic asthma (2011) J. Clin. Invest., 121, pp. 3133-3143