Reference : Modelling the influence of activation-induced apoptosis of CD4+ and CD8+ T-cells on t...
Scientific journals : Article
Engineering, computing & technology : Computer science
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/13584
Modelling the influence of activation-induced apoptosis of CD4+ and CD8+ T-cells on the immune system response of a HIV-infected patient
English
Stan, Guy-Bart [ > > ]
Belmudes, Florence mailto [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation >]
Fonteneau, Raphaël mailto [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation >]
Zeggwagh, Frédéric [ > > ]
Lefebvre, Marie-Anne [ > > ]
Michelet, Christian [ > > ]
Ernst, Damien mailto [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation >]
Mar-2008
IET Systems Biology
Institution of Engineering & Technology
2
2
94-102
Yes (verified by ORBi)
International
1751-8849
[en] HIV ; mathematical modelling ; apoptosis
[en] On the basis of the human immunodeficiency virus (HIV) infection dynamics model proposed by Adams, the authors propose an extended model that aims at incorporating the influence of activation-induced apoptosis of CD4+ and CD8+ T-cells on the immune system response of HIV-infected patients. Through this model, the authors study the influence of this phenomenon on the time evolution of specific cell populations such as plasma concentrations of HIV copies, or blood concentrations of CD4+ and CD8+ T-cells. In particular, this study shows that depending on its intensity, the apoptosis phenomenon can either favour or mitigate the long-term evolution of the HIV infection.
http://hdl.handle.net/2268/13584
10.1049/iet-syb:20070029

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