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| Reference : Isolation and pharmacological activity of phenylpropanoid esters from Marrubium vulgare |
| Scientific journals : Article | |||
| Human health sciences : Pharmacy, pharmacology & toxicology Physical, chemical, mathematical & earth Sciences : Chemistry Life sciences : Phytobiology (plant sciences, forestry, mycology...) | |||
| http://hdl.handle.net/2268/13574 | |||
| Isolation and pharmacological activity of phenylpropanoid esters from Marrubium vulgare | |
| English | |
| Sahpaz, S. [> > > >] | |
Garbacki, Nancy  [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Protéines et glycoprot. de matr.extracell. et membran.basal. >] | |
| Tits, Monique [Université de Liège - ULg > Département de pharmacie > Phytochimie et phytothérapie >] | |
| Bailleul, F. [> > > >] | |
| Mar-2002 | |
| Journal of Ethnopharmacology | |
| Elsevier Sequoia | |
| 79 | |
| 3 | |
| 389-392 | |
| International | |
| 0378-8741 | |
| Limerick | |
| Ireland | |
| [en] Marrubium vulgare ; phenylpropanoid esters ; anti-inflammatory activity ; cyclooxygenase | |
| [en] The isolation and identification of major phenylpropanoid esters from Marrubium vulgare: (+) (E)-caffeoyl-L-malic acid 1, acteoside 2, forsythoside B 3, arenarioside 4, ballotetroside 5, as well as their anti-inflammatory activity are reported for the first time, We evaluated the inhibitory effects of these five compounds on cyclooxygenase (Cox) catalysed prostaglandin biosynthesis activity. Only the glycosidic phenylpropanoid esters showed an inhibitory activity towards the Cox-2 enzyme and three of them: acteoside 2, forsythoside B 3, arenarioside 4, exhibited higher inhibitory potencies on Cox-2 than on Cox-1. These results are of interest, as Cox-2 is mainly associated with inflammation and the Cox-1 inhibition with adverse side effects often observed with non-steroidal anti-inflammatory drugs. The occurence of these phenylpropanoid esters could also explain some other pharmacological properties of M. vulgare. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved. | |
| http://hdl.handle.net/2268/13574 |
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