Reference : Evidence of association between interferon regulatory factor 5 gene polymorphisms and as...
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/135732
Evidence of association between interferon regulatory factor 5 gene polymorphisms and asthma.
English
Wang, Chuan [> >]
Rose-Zerilli, Matthew J. [> >]
Koppelman, Gerard H. [> >]
Sandling, Johanna K. [> >]
Holloway, John W. [> >]
Postma, Dirkje S. [> >]
Holgate, Stephen T. [> >]
BOURS, Vincent mailto [Centre Hospitalier Universitaire de Liège - CHU > > Génétique >]
Syvanen, Ann-Christine [> >]
Dideberg, Vinciane mailto [Centre Hospitalier Universitaire de Liège - CHU > > > > >]
2012
Gene
504
2
220-5
Yes (verified by ORBi)
International
0378-1119
Netherlands
[en] Asthma is a heterogeneous disorder hallmarked by chronic inflammation in the respiratory system. Exacerbations of asthma are correlated with respiratory infections. Considering the implication of interferon regulatory factor 5 (IRF5) in innate and adaptive immunity, we investigated the preferential transmission patterns of ten IRF5 gene polymorphisms in two asthmatic family cohorts. A common IRF5 haplotype was found to be associated with asthma and the severity of asthmatic symptoms. Stratified analysis of subgroups of asthmatic individuals revealed that the associations were more pronounced in nonatopic asthmatic individuals. In addition, the risk alleles of IRF5 polymorphisms for asthma were almost completely opposite to those for autoimmune disorders. Our study provides the first evidence of association between IRF5 and asthma, and sheds light on the related but potentially distinct roles of IRF5 alleles in the pathogenesis of asthma and autoimmune disorders.
http://hdl.handle.net/2268/135732
Copyright (c) 2012 Elsevier B.V. All rights reserved.

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