Article (Scientific journals)
16-kDa prolactin and bromocriptine in postpartum cardiomyopathy.
Hilfiker-Kleiner, Denise; Struman, Ingrid; Hoch, Melanie et al.
2012In Current Heart Failure Reports, 9 (3), p. 174-82
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Abstract :
[en] Peripartum cardiomyopathy (PPCM) is a potentially life-threatening heart disease emerging toward the end of pregnancy or in the first postpartal months in previously healthy women. Recent data suggest a central role of unbalanced peri-/postpartum oxidative stress that triggers the proteolytic cleavage of the nursing hormone prolactin (PRL) into a potent antiangiogenic, proapoptotic, and proinflammatory 16-kDa PRL fragment. This notion is supported by the observation that inhibition of PRL secretion by bromocriptine, a dopamine D2-receptor agonist, prevented the onset of disease in an animal model of PPCM and by first clinical experiences where bromocriptine seem to exert positive effects with respect to prevention or treatment of PPCM patients. Here, we highlight the current state of knowledge on diagnosis of PPCM, provide insights into the biology and pathophysiology of 16-kDa PRL and bromocriptine, and outline potential consequences for the clinical management and treatment options for PPCM patients.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Hilfiker-Kleiner, Denise
Struman, Ingrid  ;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Hoch, Melanie
Podewski, Edith
Sliwa, Karen
Language :
English
Title :
16-kDa prolactin and bromocriptine in postpartum cardiomyopathy.
Publication date :
2012
Journal title :
Current Heart Failure Reports
ISSN :
1546-9530
eISSN :
1546-9549
Publisher :
Current Science, United States
Volume :
9
Issue :
3
Pages :
174-82
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 28 November 2012

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