Reference : Epidermal Calprotectin Expression in Lymphocyte-Depleted Cutaneous Graft-versus-Host Rea...
Scientific journals : Article
Human health sciences : Hematology
http://hdl.handle.net/2268/13528
Epidermal Calprotectin Expression in Lymphocyte-Depleted Cutaneous Graft-versus-Host Reaction
English
Pierard, Gérald [Université de Liège - ULg > Département des sciences cliniques > Dermatopathologie >]
Nikkels, Nazli [Centre Hospitalier Universitaire de Liège - CHU > > Dermatologie >]
Nikkels, Arjen [Université de Liège - ULg > Département des sciences cliniques > Dermatologie >]
Arrese Estrada, Jorge [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Pierard, Claudine [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
Jerusalem, Guy [Centre Hospitalier Universitaire de Liège - CHU > > Oncologie médicale >]
Beguin, Yves mailto [Université de Liège - ULg > Département des sciences cliniques > Hématologie - Oncologie médicale >]
Fillet, Georges [Université de Liège - ULg > Département des sciences cliniques > Hématologie - Oncologie médicale >]
1998
Archivos Argentinos de Dermatologia
48
139-142
Yes (verified by ORBi)
International
0066-6750
Buenos Aires
Argentina
[en] One of the most important complications associated with bone marrow transplantation (BMT) is graft-versus-host reaction (GVHR) altering different organs. The immunosuppressive regimen frequently abates the severity of cutaneous lesions to a peculiar lymphocyto-depleted GVHR (LD-GVHR) with scant recognizable inflammatory cells and almost absence of epidermal injury. The recently revisited histological criteria for cutaneous GVHR are of little help in diagnosing such LD-GVHR. As calprotectin (L1-protein) has been reported to be expressed in several types of stressed epithelia, we assessed the epidermal calprotectin expression during LD-GVHR. Calprotectin expression was studied by immuno-histochemistry using the Mac 287 moAb in 50 cases of LD-GVHR and 40 cases of toxic reactions due to the conditioning regimens or to post-transplant drugs. Calprotectin was evidenced in normal looking keratinocytes of all cutaneous LD-GVHR cases and in the vast majority of cytotoxic drug-induced dermatitis. It is concluded that calprotectin immunoreactivity appears to be a diagnostic clue in LD-GVHR. The epidermal calprotectin expression occurs early in GVHD, irrespective of the histological grading. However, it cannot be used alone to distinguish early LD-GVHR from drug-induced dermatitis.
http://hdl.handle.net/2268/13528

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