Reference : p27(Kip1) Is a Microtubule-Associated Protein that Promotes Microtubule Polymerizatio...
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/135002
p27(Kip1) Is a Microtubule-Associated Protein that Promotes Microtubule Polymerization during Neuron Migration.
English
Godin, Juliette mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Thomas, Noemie [> >]
Laguesse, Sophie mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Malinouskaya, Lina [> >]
Close, Pierre mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Malaise, Olivier [> >]
Purnelle, Audrey [> >]
Raineteau, Olivier [> >]
Campbell, Kenneth [> >]
Fero, Matthew [> >]
Moonen, Gustave mailto [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
Malgrange, Brigitte mailto [Université de Liège - ULg > > GIGA - Neurosciences >]
Chariot, Alain mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Metin, Christine [> >]
Besson, Arnaud [> >]
Nguyen, Laurent mailto [Université de Liège - ULg > > GIGA - Neurosciences >]
2012
Developmental Cell
23
4
729-44
Yes (verified by ORBi)
International
1534-5807
United States
[en] The migration of cortical interneurons is characterized by extensive morphological changes that result from successive cycles of nucleokinesis and neurite branching. Their molecular bases remain elusive, and the present work describes how p27(Kip1) controls cell-cycle-unrelated signaling pathways to regulate these morphological remodelings. Live imaging reveals that interneurons lacking p27(Kip1) show delayed tangential migration resulting from defects in both nucleokinesis and dynamic branching of the leading process. At the molecular level, p27(Kip1) is a microtubule-associated protein that promotes polymerization of microtubules in extending neurites, thereby contributing to tangential migration. Furthermore, we show that p27(Kip1) controls actomyosin contractions that drive both forward translocation of the nucleus and growth cone splitting. Thus, p27(Kip1) cell-autonomously controls nucleokinesis and neurite branching by regulating both actin and microtubule cytoskeletons.
http://hdl.handle.net/2268/135002
Copyright (c) 2012 Elsevier Inc. All rights reserved.

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