Reference : Placental growth factor: a tissue modelling factor with therapeutic potentials in neu...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/134913
Placental growth factor: a tissue modelling factor with therapeutic potentials in neurology?
English
Chaballe, Linda mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie]
Schoenen, Jean mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie]
Franzen, Rachelle mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie]
2011
Acta Neurologica Belgica
Acta Medica Belgica
111
1
10-7
Yes (verified by ORBi)
International
0300-9009
Bruxelles
Belgique
[en] Animals ; Disease Models, Animal ; Humans ; Mice ; Models, Biological ; Nervous System Diseases/drug therapy/metabolism ; Neuroglia/drug effects/physiology ; Neurology ; Neuroprostanes/metabolism/therapeutic use ; Pregnancy Proteins/chemistry/metabolism/therapeutic use ; Receptors, Vascular Endothelial Growth Factor/metabolism/therapeutic use
[en] Placental growth factor (PlGF) is an angiogenic factor that belongs to the vascular endothelial growth factor (VEGF) family. Besides its well known capacity to potentiate the angiogenic action of VEGF, PlGF also participates in inflammatory processes by attracting and activating monocytes; it plays therefore more specifically a role in pathological conditions. PIGF and its two receptors, VEGFR-1 and neuropilins (NRPs), are expressed in the brain and increase after experimental stroke, but their precise functions in the nervous system remain underexplored. In this review article, we summarize present knowledge on the role of PlGF in various nervous system disease processes. Given the available data, P1GF has neuroprotective and neurotrophic properties that make it an actor of considerable interest in the pathophysiology and potentially in the therapy of degenerative and traumatic brain or spinal cord diseases.
http://hdl.handle.net/2268/134913

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