[en] Background: Patients with anorexia nervosa (AN) are at high risk of renal failure. Glomerular filtration rate (GFR) is overestimated when estimated by the creatinine-based equations. We have studied the accuracy and precision of cystatin C-based equations. Method: 27 AN patients were included. GFR was measured with the chromium-51-ethylenediaminetetraacetate (51Cr-EDTA) method. We have compared the accuracy and precision of creatinine-based equations (MDRD and Cockcroft) with those of different new cystatin C-based equations. Results: The creatinine-based equations overestimate measured GFR, especially the MDRD study equation. All the cystatin C-based equations also overestimate measured GFR. The Cockcroft and Gault formula and the cystatin C-based equation published by Rule have the best accuracy and precision, but these last performances remain unsatisfactory. Conclusion: Both creatinine and cystatin C-based equations strongly overestimate measured in patients with AN.
Disciplines :
Urology & nephrology
Author, co-author :
Delanaye, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Néphrologie
Cavalier, Etienne ; Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale
Radermecker, Régis ; Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques
Paquot, Nicolas ; Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques
Depas, Gisèle ; Centre Hospitalier Universitaire de Liège - CHU > Médecine nucléaire
Chapelle, Jean-Paul ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Scheen, André ; Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Krzesinski, Jean-Marie ; Université de Liège - ULiège > Département des sciences cliniques > Néphrologie
Language :
English
Title :
Estimation of GFR by different creatinine- and cystatin-C-based equations in anorexia nervosa.
Publication date :
2009
Journal title :
Clinical Nephrology
ISSN :
0301-0430
Publisher :
Dustri-Verlag Dr. Karl Feistle GmbH & Co., KG, Munchen, Germany
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