Reference : Evolution of blood myeloperoxidase in the perioperative period of horses undergoing e...
Scientific congresses and symposiums : Poster
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/134602
Evolution of blood myeloperoxidase in the perioperative period of horses undergoing emergency celiotomy.
English
[fr] Evolution de la myéloperoxidase sanguine durant la période péri opératoire de chevaux opérés en urgence pour coliques.
Salciccia, Alexandra mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Clinique équine, chirurgie > >]
Grulke, Sigrid mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Département clinique des animaux de compagnie et des équidés >]
de la Rebière de Pouyade, Geoffroy mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux >]
Verwilghen, Denis [Université de Liège - ULg > Clinique des animaux de compagnie et des équidés > Chirurgie équine > >]
Serteyn, Didier mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux >]
Jul-2009
Yes
No
International
18th Annual Scientific Meeting of ECVS
2-4 juillet 2009
ECVS
Nantes
France
[en] myeloperoxidase ; colic ; horse
[en] Colic can cause an activation of neutrophils with release in the blood flow of myeloperoxidase (MPO), a specific enzyme with strong oxidative activity. The aim of this study was to describe the evolution of plasma MPO after colic surgery. Materials included 13 adult horses that underwent an emergency celiotomy for acute intestinal obstruction. Venous blood samples were collected into EDTA anticoagulated tubes before surgery, during surgery after correction of the intestinal lesion and during the recovery of anaesthesia. In the postoperative period samples were taken every 4 hours during the first 4 days (from day 0 until day 4), every 12 hours during the days 4 and 5 and every 24 hours until day 10. MPO was assayed with a specific enzyme-linked immunosorbent assay. Statistical analysis was performed by one way Anova with student- Newman-Keuls post test on data obtained for each time point. Significance was set at p < 0.05. The horses were operated for an obstruction strangulated or not of the small or the large intestine. In six cases the postoperative period was uneventful, the 7 remaining developed one or 2 severe complications. Eight horses were discharged and 5 died during the hospitalization.The general aspect of the curve of mean plasmatic MPO can be described as follow: An increase was observed from the admission on until a peak of concentration occurring generally during the time of recovery from the anaesthesia with the highest mean value reaching 740.84 +/- 507.61ng/ml. This was followed by a progressive decrease until the lowest value, usually near to day 2 after the recovery from anaesthesia corresponding to 171.79 +/- 76.21 ng/ml of MPO. Afterwards, the mean concentrations increased slowly until postoperative day 10. In the majority of cases a stable and low MPO value (plateau) was observed during approximately 2 days (from day 1 to day 3 postoperatively).The initial peak of MPO after surgery could be associated to the neutrophil activation consequent to the intestinal disorder and the intense stimulation of the coeliotomy. The following significant reduction in concentration could be attributed to MPO infiltration into the tissues with a critical point at approximately 2 days after surgery. This study may contribute to a better understanding of the role of the MPO and neutrophils in the pathophysiology of horses in the postoperative period after colic surgery.
Centre de l’Oxygène, Recherche et Développement - CORD ; Clinique équine, FMV
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/134602

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