Reference : Behavior in the open field predicts the number of KCl-induced cortical spreading depress...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/134503
Behavior in the open field predicts the number of KCl-induced cortical spreading depressions in rats.
English
Bogdanov, Volodymyr Borysovych [> >]
Bogdanova, Olena Viktorivna [> >]
Koulchitsky, Stanislav mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Pharmacologie >]
Chauvel, Virginie mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
Multon, Sylvie mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie >]
Makarchuk, Mykola Yukhymovych [> >]
Brennan, Kevin Christopher [> >]
Renshaw, Perry Franklin [> >]
Schoenen, Jean mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie >]
2013
Behavioural Brain Research
236
1
90-3
Yes (verified by ORBi)
International
0166-4328
Netherlands
[en] Anxiety disorders are known to be comorbid with migraine, and cortical spreading depression (CSD) is the most likely cause of the migraine aura. To search for possible correlations between susceptibility to CSD and anxiety we used the open field test in male Sprague-Dawley rats chronically treated with the preventive anti-migraine drugs valproate or riboflavin. Animals avoiding the central area of the open field chamber and those with less exploratory activity (i.e. rearing) were considered more anxious. After 4 weeks of treatment CSDs were elicited by application of 1M KCl over the occipital cortex and the number of CSDs occurring over a 2h period was compared to the previously assessed open field behavior. Higher anxiety-like behavior was significantly correlated with a higher frequency of KCl-induced CSDs. In saline-treated animals, fewer rearings were found in animals with more frequent CSDs (R=-1.00). The duration of ambulatory episodes in the open field center correlated negatively with number of CSDs in the valproate group (R=-0.83; p<0.005) and in riboflavin treated group (R=-0.69; p<0.05) as well as total time spent in the open field center in both groups (R=-0.75; p<0.05 and R=-0.58; p<0.1 respectively). These results suggest that anxiety symptoms are associated with susceptibility to CSD and might explain why it can be an aggravating factor in migraine with aura.
http://hdl.handle.net/2268/134503
Copyright (c) 2012 Elsevier B.V. All rights reserved.

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