Reference : Membrane-Type 4 Matrix Metalloproteinase (MT4-MMP) induces lung metastasis by alterat...
Scientific journals : Article
Human health sciences : Reproductive medicine (gynecology, andrology, obstetrics)
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
http://hdl.handle.net/2268/13387
Membrane-Type 4 Matrix Metalloproteinase (MT4-MMP) induces lung metastasis by alteration of primary breast tumor vascular architecture
English
Chabottaux, Vincent [> >]
Ricaud, Stéphanie [> >]
Host, Lorin [> > > >]
Blacher, Silvia mailto [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Paye, Alexandra mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
Thiry, Marc mailto [Université de Liège - ULg > Département des sciences de la vie > Biologie cellulaire >]
Anikitos, G. [> >]
Pestourie, C. [> >]
Gombert, K. [> >]
Bruyere, Françoise [> >]
Lewandowsky, D. [> >]
Tavitian, B. [> >]
Foidart, Jean-Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement >]
Duconge, F. [> >]
Noël, Agnès mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
2009
Journal of Cellular & Molecular Medicine
Blackwell Publishing
Yes (verified by ORBi)
International
1582-1838
[en] MT-MMP ; breast cancer ; angiogenesis ; metastasis ; vessel architecture
[en] The present study aims at investigating the mechanism by which MT4-MMP, a membrane-anchored MMP expressed by human breast tumor cells promotes the metastatic dissemination into lung. We applied experimental (intravenous) and spontaneous (subcutaneous) models of lung metastasis using human breast adenocarcinoma MDA-MB-231 cells overexpressing or not MT4-MMP. We found that MT4-MMP does not affect lymph node colonization nor extravasation of cells from the bloodstream, but increases the intravasation step leading to metastasis. Ultrastructural and fluorescent microscopic observations coupled with automatic computer-assisted quantifications revealed that MT4-MMP expression induces blood vessel enlargement and promotes the detachment of mural cells from the vascular tree, thus causing an increased tumor vascular leak. On this basis, we propose that MT4-MMP promotes lung metastasis by disturbing the tumor vessel integrity and thereby facilitating tumor cell intravasation.
http://hdl.handle.net/2268/13387
10.1111/j.1582-4934.2009.00764.x
FP7 ; 201279 - MICROENVIMET - Understanding and fighting metastasis by modulating the tumour microenvironment through interference with the protease network.

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