Reference : Modulating effect of COMT genotype on the brains regions underlying inhibition
Scientific congresses and symposiums : Unpublished conference
Human health sciences : Neurology
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/133631
Modulating effect of COMT genotype on the brains regions underlying inhibition
English
Jaspar, Mathieu mailto [Université de Liège - ULg > Département de Psychologie : cognition et comportement > Neuropsychologie >]
Grandjean, Julien [Université de Liège - ULg > Département de Psychologie : cognition et comportement > Neuropsychologie >]
SALMON, Eric mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Maquet, Pierre mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Collette, Fabienne mailto [Université de Liège - ULg > Département de Psychologie : cognition et comportement > Neuropsychologie >]
May-2012
No
No
International
BAPS - Sepex 1st joint meeting
10 et 11 mai 2012
[en] Genetic ; COMT ; Inhibition
[en] Catechol-O-methyltransferase (COMT) is an important enzyme which degrades catecholamines, such dopamine, notably in the prefrontal cortex (Männistö & Kaakkola, 1999). A large number of studies reported an effect on executive functioning of COMT genotype (Barnett & al., 2007), each genotype being associated with a different COMT enzymatic activity (Weinshilboum & al., 1999).
In an event-related fMRI study, a modified form of the Stroop task was administered to 45 young adults separated in three groups according to their COMT val158met genotype : 15 homozygous val/val (VV), 15 homozygous met/met (MM) and 15 heterozygotes val/met (VM).
Both behavioral and fMRI results indicated the presence of a general interference effect consistent with prior reports (Nee & al., 2007). More interestingly, group comparisons indicate that this effect is associated, for a similar behavioral performance, with increased medial frontal and precentral gyrus activity in VV and VM groups by comparison with MM group. Conversely, no supplementary brain areas were observed for the comparison of the MM to the two other groups.
These observations, paralleling with the lower COMT enzymatic activity and, thus, the higher cortical dopamine level in met/met individuals, confirms our expectation of a COMT Val158Met genotype modulation of the brain regions underlying inhibition efficiency.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Interuniversity Attraction Poles - PAI
Researchers
http://hdl.handle.net/2268/133631

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