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| Reference : Arterial dP/dtmax accurately reflects left ventricular contractility during shock when a... |
| Scientific journals : Article | |||
| Human health sciences : Anesthesia & intensive care | |||
| http://hdl.handle.net/2268/133435 | |||
| Arterial dP/dtmax accurately reflects left ventricular contractility during shock when adequate vascular filling is achieved | |
| English | |
MORIMONT, Philippe  [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine >] | |
| LAMBERMONT, Bernard [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine >] | |
| Desaive, Thomas [Université de Liège - ULg > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles >] | |
| JANSSEN, Nathalie [Centre Hospitalier Universitaire de Liège - CHU > > Urgences >] | |
| Chase, J. Geoffrey [Mechanical Engineering Department, University of Canterbury, Christchurch, New Zealand] | |
| D'Orio, Vincenzo [Université de Liège - ULg > Département des sciences cliniques > Médecine d'urgence - bioch. et phys. hum. normales et path. >] | |
| 2012 | |
| BMC Cardiovascular Disorders | |
| 12:13 | |
| Yes (verified by ORBi) | |
| International | |
| 1471-2261 | |
| [en] Aortic pressure ; Endotoxin-induced shock ; Left ventricular function ; Preload responsiveness ; Septic cardiomyopathy | |
| [en] Background: Peak first derivative of femoral artery pressure (arterial dP/dt
max) derived from fluid-filled catheter remains questionable to assess left ventricular (LV) contractility during shock. The aim of this study was to test if arterial dP/dt maxis reliable for assessing LV contractility during various hemodynamic conditions such as endotoxin-induced shock and catecholamine infusion.Methods: Ventricular pressure-volume data obtained with a conductance catheter and invasive arterial pressure obtained with a fluid-filled catheter were continuously recorded in 6 anaesthetized and mechanically ventilated pigs. After a stabilization period, endotoxin was infused to induce shock. Catecholamines were transiently administrated during shock. Arterial dP/dt maxwas compared to end-systolic elastance (Ees), the gold standard method for assessing LV contractility.Results: Endotoxin-induced shock and catecholamine infusion lead to significant variations in LV contractility. Overall, significant correlation (r = 0.51; p < 0.001) but low agreement between the two methods were observed. However, a far better correlation with a good agreement were observed when positive-pressure ventilation induced an arterial pulse pressure variation (PPV) ≤ 11% (r = 0.77; p < 0.001).Conclusion: While arterial dP/dt maxand Ees were significantly correlated during various hemodynamic conditions, arterial dP/dt maxwas more accurate for assessing LV contractility when adequate vascular filling, defined as PPV ≤ 11%, was achieved. © 2012 Morimont et al; licensee BioMed Central Ltd. | |
| http://hdl.handle.net/2268/133435 | |
| 10.1186/1471-2261-12-13 |
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