Reference : Assessment of ventricular contractility and ventricular-arterial coupling with a model-b...
Scientific journals : Article
Engineering, computing & technology : Multidisciplinary, general & others
http://hdl.handle.net/2268/133434
Assessment of ventricular contractility and ventricular-arterial coupling with a model-based sensor.
English
Desaive, Thomas mailto [Université de Liège - ULg > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles]
LAMBERMONT, Bernard mailto [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine]
JANSSEN, Nathalie mailto [Centre Hospitalier Universitaire de Liège - CHU > > Urgences]
GHUYSEN, Alexandre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Urgences >]
Kolh, Philippe mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, humaines et path.]
MORIMONT, Philippe mailto [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine]
Dauby, Pierre mailto [Université de Liège - ULg > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles]
Starfinger, C [> > > >]
Shaw, GM [> > > >]
Chase, JG [> > > >]
2013
Computer Methods & Programs in Biomedicine
Elsevier Scientific
109
2
Yes (verified by ORBi)
International
0169-2607
Limerick
Ireland
[en] Estimation of ventricular contractility and ventricular arterial coupling is clinically important in diagnosing and treating cardiac dysfunction in the critically ill. However, experimental assessment of indexes of ventricular contractility, such as the end-systolic pressure-volume relationship, requires a highly invasive maneuver and measurements that are not typical in an intensive care unit (ICU). This research describes the use of a previously validated cardiovascular system model and parameter identification process to evaluate the right ventricular arterial coupling in septic shock. Model-based ventricular arterial coupling is defined by the ratio of the end systolic right ventricular elastance (E(esrvf)) over the pulmonary artery elastance (E(pa)) or the mean pulmonary inflow resistance (R(pulin)). Results are compared to the clinical gold-standard assessment (conductance catheter method). Six anesthetized healthy pigs weighing 20-30kg received a 0.5mgkg(-1) endotoxin infusion over a period of 30min from T0 to T30, to induce septic shock and veno-venous hemofiltration was used from T60 onward. The results show good agreement with the gold-standard experimental assessment. In particular, the model-based right ventricular elastance (E(esrvf)) correlates well with the clinical gold standard (R(2)=0.69) and the model-based non-invasive coupling (E(esrvf)/R(pulin)) follow the same trends and dynamics (R(2)=0.37). The overall results show the potential to develop a model-based sensor to monitor ventricular-arterial coupling in clinical real-time.
http://hdl.handle.net/2268/133434
10.1016/j.cmpb.2011.11.009
Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
CMPB-coupling-postprint-author.pdfAuthor postprint2.83 MBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.