Reference : Utilisation des microsphères biodégradables en thérapie anti-cancéreuse expérimentale...
Scientific journals : Article
Human health sciences : Oncology
Utilisation des microsphères biodégradables en thérapie anti-cancéreuse expérimentale. Application chronopharmacologique
[en] Use of Biodegradable Microspheres in Experimental Anticancer Therapy. Chronopharmacological Application
Milis, G. [> > > >]
Grandfils, Christian mailto [Université de Liège - ULg > > Biochimie et physiologie générale >]
Flandroy, P. [> > > >]
Barbason, Hervé [Université de Liège - ULg > > Relations académiques et scientifiques (Médecine) >]
Pathologie Biologie
Yes (verified by ORBi)
[en] Drug delivery system ; microparticle ; Cancer therapy
[en] We describe the initial experimentations which show that is possible to chronomodulate the cisplatin liberation out of some microspheres. The goal is to generate, inside one tumeur embolished by those cisplatin loaded microspheres, some concentration peaks at the best tolerance time. The cancer is than more hit, by the high local anticancer drug concentration, and doses chronomodulations preserve the patient by following his tolerance. The experimentation on cancerous mice show that this technique could lead to great survival increases. Such a protocol might usefuly improve the anticancer therapy.
Centre Interfacultaire des Biomatériaux - CEIB
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Synthèse, formulation et évaluation expérimentale de nouveaux matériaux destinés aux traitements endovasculaires de lésions tumorales et vasculaires, Flandroy P., Grandfils Ch. et Jérôme R.. Subvention FRSM : 3.4553.91 (1991-1994

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