Reference : Optimization of poly(2-(dimethylamino)ethyl methacrylate)-co-poly(ethyleneglycol)/DNA...
Scientific journals : Article
Life sciences : Biotechnology
Life sciences : Microbiology
http://hdl.handle.net/2268/133379
Optimization of poly(2-(dimethylamino)ethyl methacrylate)-co-poly(ethyleneglycol)/DNA complexes designed for cell transfection
English
Grandfils, Christian mailto [Université de Liège - ULg > > Biochimie et physiologie générale >]
Emonds-Alt, J. [> > > >]
Dec-2005
Minerva Biotecnologica
Edizioni Minerva Medica
17
4
237-243
Yes
International
1120-4826
Turin
[en] cell transfection ; polycation ; gene delivery ; polyelectrolyte complex
[en] Cell transfection relies upon the delivery of genomic material within cells in order to express selected DNA sequences. Non-viral gene delivery systems are preferable over viral vectors for several reasons: biosafety, low immunogenicity, higher loading capacity, and easiness of production. Their major drawbacks actually are their limited efficiency in vivo compared to viruses, their cytotoxicity and the fact that they are rapidly cleared up from the bloodstream. The aim of our study was to better characterize the physico-chemical behavior of the polycations based on poly(2-(dimethylamino)ethyl methacrylate)-co-poly(ethyleneglycol) and to control the formulation step to produce the polyelectrolyte complexes.
Centre Interfacultaire des Biomatériaux - CEIB
DG06
Nouveaux polycations et vectorisation d’ADN dans les cellules de parois vasculaires” Convention Région Wallonne n° 14612, année 2001-2004 dans le cadre du concours Initiative 2000
http://hdl.handle.net/2268/133379

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