Article (Scientific journals)
Brain activation pattern related to gait disturbances in Parkinson's disease.
Cremers, Julien; D'Ostilio, Kevin; Stamatakis, Julien et al.
2012In Movement Disorders, 27 (12), p. 1498-505
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Keywords :
parkinson; fMRI; gait
Abstract :
[en] Gait disturbances represent a therapeutic challenge in Parkinson's disease (PD). To further investigate their underlying pathophysiological mechanisms, we compared brain activation related to mental imagery of gait between 15 PD patients and 15 age-matched controls using a block-design functional MRI experiment. On average, patients showed altered locomotion relatively to controls, as assessed with a standardized gait test that evaluated the severity of PD-related gait disturbances on a 25-m path. The experiment was conducted in the subjects as they rehearsed themselves walking on the same path with a gait pattern similar as that during locomotor evaluation. Imagined walking times were measured on a trial-by-trial basis as a control of behavioral performance. In both groups, mean imagined walking time was not significantly different from that measured during real gait on the path used for evaluation. The between-group comparison of the mental gait activation pattern with reference to mental imagery of standing showed hypoactivations within parieto-occipital regions, along with the left hippocampus, midline/lateral cerebellum, and presumed pedunculopontine nucleus/mesencephalic locomotor area, in patients. More specifically, the activation level of the right posterior parietal cortex located within the impaired gait-related cognitive network decreased proportionally with the severity of gait disturbances scored on the path used for gait evaluation and mental imagery. These novel findings suggest that the right posterior parietal cortex dysfunction is strongly related to the severity of gait disturbances in PD. This region may represent a target for the development of therapeutic interventions for PD-related gait disturbances. (c) 2012 Movement Disorder Society.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Radiology, nuclear medicine & imaging
Neurosciences & behavior
Neurology
Author, co-author :
Cremers, Julien ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
D'Ostilio, Kevin ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Stamatakis, Julien
DELVAUX, Valérie ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman
GARRAUX, Gaëtan  ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman
Language :
English
Title :
Brain activation pattern related to gait disturbances in Parkinson's disease.
Publication date :
2012
Journal title :
Movement Disorders
ISSN :
0885-3185
eISSN :
1531-8257
Publisher :
John Wiley & Sons, Hoboken, United States - New York
Volume :
27
Issue :
12
Pages :
1498-505
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
MJFF - Michael J. Fox Foundation for Parkinson's Research [US-NY]
Commentary :
Copyright (c) 2012 Movement Disorder Society.
Available on ORBi :
since 24 October 2012

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