ORBi: Cremers Julien - Brain activation pattern related to gait disturbances in Parkinson's disease.

Reference : Brain activation pattern related to gait disturbances in Parkinson's disease.


	Document type :	Scientific journals : Article
	Discipline(s) :	Social & behavioral sciences, psychology : Neurosciences & behavior Human health sciences : Neurology Human health sciences : Radiology, nuclear medicine & imaging
	To cite this reference:	http://hdl.handle.net/2268/132772

Title :	Brain activation pattern related to gait disturbances in Parkinson's disease.
Language :	English
Author, co-author :	Cremers, Julien [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
	D'Ostilio, Kevin [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Stamatakis, Julien [> >]
	DELVAUX, Valérie [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
	GARRAUX, Gaëtan [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Publication date :	2012
Journal title :	Movement Disorders : Official Journal of the Movement Disorder Society
Volume :	27
Issue/season :	12
Pages :	1498-505
Audience :	International
ISSN :	0885-3185
e-ISSN :	1531-8257
Country :	United States
Keywords :	[en] parkinson ; fMRI ; gait
Abstract :	[en] Gait disturbances represent a therapeutic challenge in Parkinson's disease (PD). To further investigate their underlying pathophysiological mechanisms, we compared brain activation related to mental imagery of gait between 15 PD patients and 15 age-matched controls using a block-design functional MRI experiment. On average, patients showed altered locomotion relatively to controls, as assessed with a standardized gait test that evaluated the severity of PD-related gait disturbances on a 25-m path. The experiment was conducted in the subjects as they rehearsed themselves walking on the same path with a gait pattern similar as that during locomotor evaluation. Imagined walking times were measured on a trial-by-trial basis as a control of behavioral performance. In both groups, mean imagined walking time was not significantly different from that measured during real gait on the path used for evaluation. The between-group comparison of the mental gait activation pattern with reference to mental imagery of standing showed hypoactivations within parieto-occipital regions, along with the left hippocampus, midline/lateral cerebellum, and presumed pedunculopontine nucleus/mesencephalic locomotor area, in patients. More specifically, the activation level of the right posterior parietal cortex located within the impaired gait-related cognitive network decreased proportionally with the severity of gait disturbances scored on the path used for gait evaluation and mental imagery. These novel findings suggest that the right posterior parietal cortex dysfunction is strongly related to the severity of gait disturbances in PD. This region may represent a target for the development of therapeutic interventions for PD-related gait disturbances. (c) 2012 Movement Disorder Society.
Research units :	Centre de Recherches du Cyclotron - CRC
Funders :	Michael J. Fox Fondation, USA
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/132772
DOI :	10.1002/mds.25139
Commentary :	Copyright (c) 2012 Movement Disorder Society.

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