Reference : Sleep in the unresponsive wakefulness syndrome and minimally conscious state
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/132759
Sleep in the unresponsive wakefulness syndrome and minimally conscious state
English
[fr] Le sommeil dans le syndrome d'éveil non répondant et l'état de conscience minimale
Cologan, Victor [Université de Liège - ULg > > > Accès au site http://www.coma.ulg.ac.be/data]
Drouot, Xavier mailto [Hôpital Henri Mondor, Paris, France > Neurologie > Centre du sommeil > >]
Parapatics, Silvia mailto [Université médicale de Vienne > Psychiatrie et psychothérapie > > >]
Delorme, Arnaud mailto [Centre National de la Recherche Scientifique - CNRS > CERCO > > >]
Gruber, Georg mailto [Université médicale de Vienne, Autriche > Psychiatrie et psychothérapie > > > >]
MOONEN, Gustave mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Laureys, Steven mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Mar-2013
Journal of Neurotrauma
Mary Ann Liebert, Inc.
30
5
339-346
Yes (verified by ORBi)
International
0897-7151
Larchmont
NY
[en] Consciousness ; Unresponsive wakefulness syndrome ; Minimally conscious state ; Sleep ; Trauma ; Anoxia ; Stroke ; Brain injury ; Electrophysiology
[en] The goal of our study was to investigate different aspects of sleep, namely the sleep-wake cycle
and sleep stages, in the vegetative state/unresponsive wakefulness syndrome (VS/UWS) and
minimally conscious state (MCS). 24h polysomnography was performed in 20 patients in a UWS
(n=10) or in a MCS (n=10) due to brain injury. The data were first tested for the presence of a
sleep-wake cycle and the observed sleep patterns were compared to standard scoring criteria.
Sleep spindles, slow waves sleep and rapid eye movement sleep were quantified and their clinical
value was investigated. According to our results, an electrophysiological sleep-wake cycle was
identified in 5 MCS and 3 VS/UWS patients. Sleep stages did not always match the standard
scoring criteria which therefore needed to be adapted. Sleep spindles were more present in
patients who clinically improved within 6 months. Slow wave sleep was present in 8 MCS and 3
VS/UWS patients but never in the ischemic etiology. Rapid eye movement sleep, and therefore
dreaming which is a form of consciousness, was present in all MCS and 3 VS/UWS patients. In
conclusion, the presence of alternating periods of eyes-open/eyes-closed cycles does not
necessarily imply preserved electrophysiological sleep architecture in the UWS and MCS,
contrary to previous definition. The investigation of sleep is a little studied yet simple and
informative way to evaluate the integrity of residual brain function in patients with disorders of
consciousness with possible clinical diagnostic and prognostic implications.
Centre de Recherches du Cyclotron - CRC
Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA
Le sommeil chez les patients en état de conscience altéré
Researchers ; Professionals ; Students ; General public
http://hdl.handle.net/2268/132759
10.1089/neu.2012.2654
This is the first study of sleep in brain-injured patients based on 24H polysomnography and multicentric data analysis.

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