Reference : Infection with versus exposure to Taenia solium: what do serological test results tell us?
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
Infection with versus exposure to Taenia solium: what do serological test results tell us?
Praet, Nicolas [> >]
Rodriguez-Hidalgo, Richar [> >]
Speybroeck, Niko [> >]
Ahounou, Serge [> >]
Benitez-Ortiz, Washington [> >]
Berkvens, Dirk [> >]
Hul, Anke Van [> >]
Barrionuevo-Samaniego, Margoth [> >]
Saegerman, Claude mailto [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Epidémiologie et analyse des risques appl. aux sc. vétér. >]
Dorny, Pierre [> >]
American Journal of Tropical Medicine and Hygiene (The)
Yes (verified by ORBi)
United States
[en] Animals ; Antibodies, Helminth/blood ; Bayes Theorem ; Cysticercosis/blood/diagnosis/immunology/parasitology ; Ecuador ; Enzyme-Linked Immunosorbent Assay ; Humans ; Sensitivity and Specificity ; Serologic Tests ; Taenia solium/immunology
[en] Taenia solium cysticercosis is an endemic zoonosis in many developing countries. Serological tests are the most appropriate diagnostic tools to understand the transmission dynamics of the parasite, but the performances of these methods in such a setting are not known. A south Ecuadorian human population living in an endemic area was tested using three common serological tests. Because none of them is a gold standard, a Bayesian Latent Class analysis was used to estimate the test characteristics. Two definitions of a case were considered to differentiate between prevalence of current infection and prior exposure to the parasite. Differences between the performances of the same test in function of the definition of a case were observed. This study shows that test results and prior information should be interpreted carefully in a Bayesian analysis framework, particularly when the latter is based on clinical studies.

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