Reference : Brucellosis at the animal/ecosystem/human interface at the beginning of the 21st century.
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/132503
Brucellosis at the animal/ecosystem/human interface at the beginning of the 21st century.
English
Godfroid, J. [> >]
Scholz, H. C. [> >]
Barbier, T. [> >]
Nicolas, C. [> >]
Wattiau, P. [> >]
Fretin, D. [> >]
Whatmore, A. M. [> >]
Cloeckaert, A. [> >]
Blasco, J. M. [> >]
Moriyon, I. [> >]
Saegerman, Claude mailto [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Epidémiologie et analyse des risques appl. aux sc. vétér. >]
Muma, J. B. [> >]
Al Dahouk, S. [> >]
Neubauer, H. [> >]
Letesson, J.-J. [> >]
2011
Preventive Veterinary Medicine
102
2
118-31
Yes (verified by ORBi)
0167-5877
Netherlands
[en] Animals ; Brucella/isolation & purification ; Brucellosis/epidemiology/microbiology/veterinary ; Female ; Humans ; Pregnancy ; Zoonoses/epidemiology/microbiology
[en] Following the recent discovery of new Brucella strains from different animal species and from the environment, ten Brucella species are nowadays included in the genus Brucella. Although the intracellular trafficking of Brucella is well described, the strategies developed by Brucella to survive and multiply in phagocytic and non-phagocytic cells, particularly to access nutriments during its intracellular journey, are still largely unknown. Metabolism and virulence of Brucella are now considered to be two sides of the same coin. Mechanisms presiding to the colonization of the pregnant uterus in different animal species are not known. Vaccination is the cornerstone of control programs in livestock and although the S19, RB51 (both in cattle) and Rev 1 (in sheep and goats) vaccines have been successfully used worldwide, they have drawbacks and thus the ideal brucellosis vaccine is still very much awaited. There is no vaccine available for pigs and wildlife. Animal brucellosis control strategies differ in the developed and the developing world. Most emphasis is put on eradication and on risk analysis to avoid the re-introduction of Brucella in the developed world. Information related to the prevalence of brucellosis is still scarce in the developing world and control programs are rarely implemented. Since there is no vaccine available for humans, prevention of human brucellosis relies on its control in the animal reservoir. Brucella is also considered to be an agent to be used in bio- and agroterrorism attacks. At the animal/ecosystem/human interface it is critical to reduce opportunities for Brucella to jump host species as already seen in livestock, wildlife and humans. This task is a challenge for the future in terms of veterinary public health, as for wildlife and ecosystem managers and will need a "One Health" approach to be successful.
http://hdl.handle.net/2268/132503
Copyright (c) 2011 Elsevier B.V. All rights reserved.

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