ORBi: Joly Laure - d(TG(n)T) DNA sequences do not necessarily form tetramolecular G-quadruplexes.

Reference : d(TG(n)T) DNA sequences do not necessarily form tetramolecular G-quadruplexes.


	Document type :	Scientific journals : Short communication
	Discipline(s) :	Physical, chemical, mathematical & earth Sciences : Chemistry
	To cite this reference:	http://hdl.handle.net/2268/132466

Title :	d(TG(n)T) DNA sequences do not necessarily form tetramolecular G-quadruplexes.
Language :	English
Author, co-author :	Joly, Laure [> >]
	Rosu, Frédéric [Université de Liège - ULg > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.) >]
	Gabelica, Valérie [Université de Liège - ULg > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.) >]
Publication date :	2012
Journal title :	Chemical Communications
Volume :	48
Issue/season :	67
Pages :	8386-8
Audience :	International
ISSN :	1359-7345
e-ISSN :	1364-548X
Country :	England
Keywords :	[en] mass spectrometry ; G-quadruplex ; electrospray ; self-assembly ; mechanism
Abstract :	[en] Contrasting with the common belief that d(TG(n)T) DNA sequences would form tetramolecular G-quadruplex assemblies, mass spectrometry reveals that these sequences tend to fold into G-quadruplex trimers, dimers, and eventually monomers as the G-tract length increases. The final structure also depends on the ionic strength.
Research units :	DER Chimie ; Giga-Systems Biology and Chemical Biology
Funders :	Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Target :	Researchers ; Professionals ; Students
Permalink :	http://hdl.handle.net/2268/132466
DOI :	10.1039/c2cc33316c

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