Reference : A novel phase portrait for neuronal excitability
Scientific journals : Article
Human health sciences : Multidisciplinary, general & others
http://hdl.handle.net/2268/132438
A novel phase portrait for neuronal excitability
English
Drion, Guillaume mailto [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Dép. d'électric., électron. et informat. (Inst.Montefiore) >]
Franci, Alessio mailto [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation >]
Seutin, Vincent mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Pharmacologie >]
Sepulchre, Rodolphe mailto [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation >]
Aug-2012
PLoS ONE
Public Library of Science
7
8
Yes (verified by ORBi)
International
1932-6203
San Franscisco
CA
[en] Phase portrait ; Neuroscience ; Bursting
[en] Fifty years ago, FitzHugh introduced a phase portrait that became famous for a twofold reason: it captured in a physiological way the qualitative behavior of Hodgkin-Huxley model and it revealed the power of simple dynamical models to unfold complex firing patterns. To date, in spite of the enormous progresses in qualitative and quantitative neural modeling, this phase portrait has remained a core picture of neuronal excitability. Yet, a major difference between the neurophysiology of 1961 and of 2011 is the recognition of the prominent role of calcium channels in firing mechanisms. We show that including this extra current in Hodgkin-Huxley dynamics leads to a revision of FitzHugh-Nagumo phase portrait that affects in a fundamental way the reduced modeling of neural excitability. The revisited model considerably enlarges the
modeling power of the original one. In particular, it captures essential electrophysiological signatures that otherwise require non-physiological alteration or considerable complexification of the classical model. As a basic illustration, the new model is shown to highlight a core dynamical mechanism by which calcium channels control the two distinct firing modes of
thalamocortical neurons.
Giga-Neurosciences
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/132438
10.1371/journal.pone.0041806
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0041806

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